Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T23666 Target Info
Target Name Aryl hydrocarbon receptor (AHR)
Synonyms bHLHe76; Class E basic helixloophelix protein 76; Class E basic helix-loop-helix protein 76; AhR; Ah receptor
Target Type Successful Target
Gene Name AHR
UniProt ID
AHR_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Yeast two hybrid [1]
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-purification [3]
2 Yeast two hybrid [4]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Protein Name Retinoblastoma-associated protein (RB1) Interacting Protein Interacting Protein Info
UniProt ID
RB_HUMAN 
Synonyms OSRC; PPP1R130; RB; p105.Rb; pRb; pp110
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [6]
3 Reconstituted Complex [7]
4 Reconstituted Complex [5]
5 Yeast two hybrid [7]
6 Yeast two hybrid [6]
7 Yeast two hybrid [5]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [9]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [11]
4 Biochemical Activity [3]
5 Co-purification [3]
6 Reconstituted Complex [12]
Transcription regulators [+] 2 Transcription regulators +
Interacting Protein Name Aryl hydrocarbon receptor nuclear translocator (ARNT) Interacting Protein Interacting Protein Info
UniProt ID
ARNT_HUMAN 
Synonyms HIF.1.beta; HIF.1beta; HIF1.beta; HIF1B; HIF1BETA; TANGO; bHLHe2
Evidence Score (E-score) 15 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [13]
4 Affinity Capture-Western [14]
5 Affinity Capture-Western [15]
6 Reconstituted Complex [16]
7 Reconstituted Complex [14]
8 Reconstituted Complex [17]
9 Reconstituted Complex [18]
10 Reconstituted Complex [19]
11 Reconstituted Complex [20]
12 Reconstituted Complex [21]
13 Reconstituted Complex [22]
14 Reconstituted Complex [23]
15 Yeast two hybrid [24]
Interacting Protein Name Nuclear receptor coactivator 2 (NCOA2) Interacting Protein Interacting Protein Info
UniProt ID
NCOA2_HUMAN 
Synonyms GRIP1; KAT13C; NCoA.2; SRC2; TIF2; bHLHe75
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Other proteins [+] 1 Other proteins +
Interacting Protein Name AH receptor-interacting protein (AIP) Interacting Protein Interacting Protein Info
UniProt ID
AIP_HUMAN 
Synonyms ARA9; FKBP16; FKBP37; SMTPHN; XAP.2; XAP2
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-Western [25]
2 Affinity Capture-Western [26]
3 Reconstituted Complex [27]
4 Reconstituted Complex [25]
5 Reconstituted Complex [28]
6 Reconstituted Complex [9]
7 Yeast two hybrid [27]
8 Yeast two hybrid [25]
9 Yeast two hybrid [29]
References  Top
REF 1 Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex. Mol Cell Biol. 2002 Jun;22(12):4319-33.
REF 2 Induced alpha-helix structure in the aryl hydrocarbon receptor transactivation domain modulates protein-protein interactions. Biochemistry. 2005 Jan 18;44(2):734-43.
REF 3 Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature. 2007 Mar 29;446(7135):562-6.
REF 4 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 5 Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. J Biol Chem. 2000 Jan 28;275(4):2943-50.
REF 6 Maximal aryl hydrocarbon receptor activity depends on an interaction with the retinoblastoma protein. Mol Pharmacol. 2001 Apr;59(4):664-73.
REF 7 A direct interaction between the aryl hydrocarbon receptor and retinoblastoma protein. Linking dioxin signaling to the cell cycle. J Biol Chem. 1998 Aug 28;273(35):22708-13.
REF 8 Role of the Per/Arnt/Sim domains in ligand-dependent transformation of the aryl hydrocarbon receptor. J Biol Chem. 2008 Nov 21;283(47):32995-3005.
REF 9 The immunophilin-like protein XAP2 regulates ubiquitination and subcellular localization of the dioxin receptor. J Biol Chem. 2000 Dec 29;275(52):41317-24.
REF 10 The aryl hydrocarbon receptor mediates degradation of estrogen receptor alpha through activation of proteasomes. Mol Cell Biol. 2003 Mar;23(6):1843-55.
REF 11 The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1. Arch Biochem Biophys. 2000 Jan 1;373(1):163-74.
REF 12 ER alpha-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription. J Biol Chem. 2005 Jun 3;280(22):21607-11.
REF 13 Benzyl butyl phthalate induces necrosis by AhR mediation of CYP1B1 expression in human granulosa cells. Reprod Toxicol. 2012 Jan;33(1):67-75.
REF 14 Establishment of a cell-free bioassay for detecting dioxin-like compounds. Toxicol Mech Methods. 2013 Jul;23(6):464-70.
REF 15 Role of heat shock protein 90 dissociation in mediating agonist-induced activation of the aryl hydrocarbon receptor. Mol Pharmacol. 2000 Jan;57(1):82-92.
REF 16 Ligand-dependent recruitment of the Arnt coregulator determines DNA recognition by the dioxin receptor. Mol Cell Biol. 1993 Apr;13(4):2504-14.
REF 17 Beta tubulin affects the aryl hydrocarbon receptor function via an Arnt-mediated mechanism. Biochem Pharmacol. 2010 Apr 15;79(8):1125-33.
REF 18 Analysis of Ah receptor-ARNT and Ah receptor-ARNT2 complexes in vitro and in cell culture. Toxicol Sci. 2008 May;103(1):191-206.
REF 19 A redox mechanism controls differential DNA binding activities of hypoxia-inducible factor (HIF) 1alpha and the HIF-like factor. J Biol Chem. 2000 Feb 18;275(7):4618-27.
REF 20 The Q-rich subdomain of the human Ah receptor transactivation domain is required for dioxin-mediated transcriptional activity. J Biol Chem. 2001 Nov 9;276(45):42302-10.
REF 21 Functional characterization of DNA-binding domains of the subunits of the heterodimeric aryl hydrocarbon receptor complex imputing novel and canonical basic helix-loop-helix protein-DNA interactions. J Biol Chem. 1996 Apr 12;271(15):8843-50.
REF 22 The aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response elements. Mol Cell Endocrinol. 1999 Nov 25;157(1-2):105-19.
REF 23 Identification of functional domains of the aryl hydrocarbon receptor nuclear translocator protein (ARNT). Mol Cell Biol. 1994 Sep;14(9):6075-86.
REF 24 Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system. Biochem Pharmacol. 1995 Oct 12;50(8):1295-302.
REF 25 A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem. 1997 Apr 4;272(14):8878-84.
REF 26 Two parallel pathways mediate cytoplasmic localization of the dioxin (aryl hydrocarbon) receptor. J Biol Chem. 2002 Aug 30;277(35):32310-9.
REF 27 Ligand-dependent interaction of the aryl hydrocarbon receptor with a novel immunophilin homolog in vivo. J Biol Chem. 1997 Apr 25;272(17):11452-6.
REF 28 Characterization of the Ah receptor-associated protein, ARA9. J Biol Chem. 1998 Dec 11;273(50):33580-7.
REF 29 The aryl hydrocarbon receptor signaling pathway is modified through interactions with a Kelch protein. Mol Pharmacol. 2006 Jul;70(1):8-15.

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