Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T23619 Target Info
Target Name Metastasis associated gene-1 (MTA1)
Synonyms Metastasisassociated protein MTA1; Metastasis-associated protein MTA1
Target Type Literature-reported Target
Gene Name MTA1
UniProt ID
MTA1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Protein Name Chromodomain-helicase-DNA-binding protein 4 (CHD4) Interacting Protein Interacting Protein Info
UniProt ID
CHD4_HUMAN 
Synonyms CHD.4; Mi.2b; Mi2.BETA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Beta-transducin repeats [+] 2 Beta-transducin repeats +
Interacting Protein Name Histone-binding protein RBBP4 (RBBP4) Interacting Protein Interacting Protein Info
UniProt ID
RBBP4_HUMAN 
Synonyms NURF55; RBAP48; lin.53
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [5]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [2]
6 Affinity Capture-Western [1]
7 Co-crystal Structure [3]
8 Co-purification [7]
9 Reconstituted Complex [3]
Interacting Protein Name Histone-binding protein RBBP7 (RBBP7) Interacting Protein Interacting Protein Info
UniProt ID
RBBP7_HUMAN 
Synonyms RbAp46
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-MS [5]
4 Affinity Capture-Western [6]
5 Affinity Capture-Western [1]
Carbon-nitrogen hydrolases [+] 2 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [1]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [2]
5 Affinity Capture-Western [1]
6 Affinity Capture-Western [9]
7 Affinity Capture-Western [10]
8 Reconstituted Complex [3]
Interacting Target Name Histone deacetylase 2 (HDAC2) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC2_HUMAN 
Synonyms HD2
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [2]
4 Affinity Capture-Western [1]
5 Affinity Capture-Western [11]
6 Affinity Capture-Western [12]
7 Affinity Capture-Western [13]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Reconstituted Complex [14]
3 Reconstituted Complex [15]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Target Name DNA [cytosine-5]-methyltransferase 1 (DNMT1) Clinical trial Target Interacting Protein Info
UniProt ID
DNMT1_HUMAN 
Synonyms MCMT; M.HsaI; Dnmt1; DNMT; DNA MTase HsaI; DNA methyltransferase HsaI; DNA (cytosine-5)-methyltransferase 1; DNA (cytosine5)methyltransferase 1; CXXC-type zinc finger protein 9; CXXCtype zinc finger protein 9; CXXC9; AIM
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Co-fractionation [17]
Oxidoreductases [+] 1 Oxidoreductases +
Interacting Target Name Lysine-specific histone demethylase 1 (LSD) Clinical trial Target Interacting Protein Info
UniProt ID
KDM1A_HUMAN 
Synonyms Lysine-specific histone demethylase 1A; Lysinespecific histone demethylase 1A; LSD1; KIAA0601; KDM1; Flavin-containing amine oxidase domain-containing protein 2; Flavincontaining amine oxidase domaincontaining protein 2; BRAF35-HDAC complex protein BHC110; BRAF35HDAC complex protein BHC110; AOF2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Reconstituted Complex [18]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [19]
2 Co-localization [20]
3 Reconstituted Complex [1]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name Hypoxia-inducible factor 1 alpha (HIF-1A) Clinical trial Target Interacting Protein Info
UniProt ID
HIF1A_HUMAN 
Synonyms Transcription factor HIF-1; PASD8; PAS domain-containing protein 8; MOP1; Member of PAS protein 1; Hypoxia-inducible transcription factor (HIF)-1; Hypoxia-inducible factor 1-alpha; Hypoxia-inducible factor 1; Hypoxia inducible factor 1; HIF-1-alpha; HIF-1alpha; HIF1-alpha; HIF-1 alpha; HIF1 alpha; Class E basic helix-loop-helix protein 78; bHLHe78; Basic-helix-loop-helix-PAS protein MOP1; ARNT-interacting protein; ARNT interacting protein
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Affinity Capture-Western [21]
3 Reconstituted Complex [21]
Interacting Target Name Transcription factor SOX-2 (SOX2) Literature-reported Target Interacting Protein Info
UniProt ID
SOX2_HUMAN 
Synonyms ANOP3; MCOPS3; SRY-box 2
Evidence Score (E-score) 1 Experimental Evidences +
1 Affinity Capture-MS [22]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Metastasis-associated protein MTA2 (MTA2) Interacting Protein Interacting Protein Info
UniProt ID
MTA2_HUMAN 
Synonyms MTA1L1; PID
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
References  Top
REF 1 The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity. J Biol Chem. 2003 Oct 24;278(43):42560-8.
REF 2 Nuclear receptors TR2 and TR4 recruit multiple epigenetic transcriptional corepressors that associate specifically with the embryonic -type globin promoters in differentiated adult erythroid cells. Mol Cell Biol. 2011 Aug;31(16):3298-311.
REF 3 The structure of the core NuRD repression complex provides insights into its interaction with chromatin. Elife. 2016 Apr 21;5:e13941.
REF 4 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 5 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 6 The zinc finger and C-terminal domains of MTA proteins are required for FOG-2-mediated transcriptional repression via the NuRD complex. J Mol Cell Cardiol. 2008 Feb;44(2):352-60.
REF 7 The MTA1 subunit of the nucleosome remodeling and deacetylase complex can recruit two copies of RBBP4/7. Protein Sci. 2016 Aug;25(8):1472-82.
REF 8 Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor. Nat Cell Biol. 2001 Jan;3(1):30-7.
REF 9 Metastasis-associated protein 1 enhances stability of hypoxia-inducible factor-1alpha protein by recruiting histone deacetylase 1. EMBO J. 2006 Mar 22;25(6):1231-41.
REF 10 Heat shock factor 1 represses estrogen-dependent transcription through association with MTA1. Oncogene. 2008 Mar 20;27(13):1886-93.
REF 11 Repression of 92-kDa type IV collagenase expression by MTA1 is mediated through direct interactions with the promoter via a mechanism, which is both dependent on and independent of histone deacetylation. J Biol Chem. 2003 Jan 24;278(4):2309-16.
REF 12 Identification of Pax5 as a target of MTA1 in B-cell lymphomas. Cancer Res. 2007 Aug 1;67(15):7132-8.
REF 13 Acetylation-dependent oncogenic activity of metastasis-associated protein 1 co-regulator. EMBO Rep. 2010 Sep;11(9):691-7.
REF 14 A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm. Nature. 2002 Aug 8;418(6898):654-7.
REF 15 Solution structure and antiestrogenic activity of the unique C-terminal, NR-box motif-containing region of MTA1s. J Biol Chem. 2006 Sep 1;281(35):25612-21.
REF 16 The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes. Oncogene. 2014 Apr 24;33(17):2157-68.
REF 17 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 18 LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer. Cell. 2009 Aug 21;138(4):660-72.
REF 19 Metastasis-associated protein 1 inhibits p53-induced apoptosis. Oncol Rep. 2007 Nov;18(5):1311-4.
REF 20 Revelation of p53-independent function of MTA1 in DNA damage response via modulation of the p21 WAF1-proliferating cell nuclear antigen pathway. J Biol Chem. 2010 Mar 26;285(13):10044-52.
REF 21 Metastasis-associated protein 1 enhances angiogenesis by stabilization of HIF-1alpha. Oncol Rep. 2006 Oct;16(4):929-35.
REF 22 Sox2 cooperates with Chd7 to regulate genes that are mutated in human syndromes. Nat Genet. 2011 Jun;43(6):607-11.

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