Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T23276 Target Info
Target Name Extracellular signal-regulated kinase 1 (ERK1)
Synonyms PRKM3; P44-MAPK; P44-ERK1; P44 Mitogen-activated protein kinase; Mitogen-activated protein kinase 3; Microtubule-associated protein-2 kinase; Microtubule-associated protein 2 kinase; MAPK 3; MAP kinase isoform p44; MAP kinase 3; Insulin-stimulated MAP2 kinase; ERT2; ERK-1
Target Type Clinical trial Target
Gene Name MAPK3
Biochemical Class Kinase
UniProt ID
MK03_HUMAN 
Target Interacting Proteins  Top
Alkyl/aryl transferases [+] 1 Alkyl/aryl transferases +
Interacting Target Name Deoxyhypusine synthase (DHPS) Literature-reported Target Interacting Protein Info
UniProt ID
DHYS_HUMAN 
Synonyms DHS
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Yeast two hybrid [4]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Dual specificity protein phosphatase 1 (DUSP1) Clinical trial Target Interacting Protein Info
UniProt ID
DUS1_HUMAN 
Synonyms VH1; PTPN10; Protein-tyrosine phosphatase CL100; MKP-1; MKP1; Mitogen-activated protein kinase phosphatase 1; MAP kinase phosphatase-1; MAP kinase phosphatase 1; Dual specificity protein phosphatase hVH1; CL100
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [5]
2 Co-localization [6]
Kinases [+] 5 Kinases +
Interacting Target Name ERK activator kinase 1 (MEK1) Clinical trial Target Interacting Protein Info
UniProt ID
MP2K1_HUMAN 
Synonyms PRKMK1; MKK1; Mitogen-activated protein kinase kinase 1; MEK 1; MAPKK 1; MAPK/ERKkinase 1; MAPK/ERK kinase 1; MAP kinase kinase 1; Dual specificity mitogen-activated protein kinase kinase 1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [9]
4 Biochemical Activity [10]
5 Co-localization [9]
Interacting Target Name Extracellular signal-regulated kinase 2 (ERK2) Clinical trial Target Interacting Protein Info
UniProt ID
MK01_HUMAN 
Synonyms PRKM2; PRKM1; P42-MAPK; P42 Mitogen-activated protein kinase; Mitogen-activated protein kinase 2; Mitogen-activated protein kinase 1; MAPK 2; MAPK 1; MAP kinase isoform p42; MAP kinase 2; MAP kinase 1; ERT1; ERK-2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [11]
3 Affinity Capture-Western [8]
Interacting Target Name ERK activator kinase 2 (MEK2) Clinical trial Target Interacting Protein Info
UniProt ID
MP2K2_HUMAN 
Synonyms PRKMK2; MKK2; MEK 2; MAPKK 2; MAPK/ERK kinase 2; MAP kinase kinase 2; Dual specificity mitogen-activated protein kinase kinase 2; Dual specificity mitogenactivated protein kinase kinase 2
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [12]
2 Reconstituted Complex [10]
3 Yeast two hybrid [13]
Interacting Target Name Stress-activated protein kinase 2a (p38 alpha) Clinical trial Target Interacting Protein Info
UniProt ID
MK14_HUMAN 
Synonyms SAPK2A; P38 Mitogen-activatedprotein kinase alpha; P38 mitogen activatedprotein kinase; MXI2; Mitogen-activated protein kinase p38 alpha; Mitogen-activated protein kinase 14; MAX-interacting protein 2; MAPK 14; MAP kinase p38alpha; MAP kinase p38 alpha; MAP kinase MXI2; MAP kinase 14; Cytokine suppressive anti-inflammatory drug-binding protein; Cytokine suppressive anti-inflammatory drug binding protein; CSPB1; CSBP2; CSBP1; CSBP; CSAID-binding protein; CSAID binding protein; CRK1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Protein-Fragment Complementation Assay [15]
Interacting Target Name Ribosomal protein S6 kinase alpha-2 (RSK2) Literature-reported Target Interacting Protein Info
UniProt ID
KS6A2_HUMAN 
Synonyms S6K-alpha-2; RSK-3; RSK3; Ribosomal S6 kinase 3; pp90RSK3; p90RSK2; p90-RSK 2; MAPKAPK-1c; MAPKAPK1C; MAPKAP kinase 1c; MAPK-activated protein kinase 1c; MAP kinase-activated protein kinase 1c; 90 kDa ribosomal protein S6 kinase 2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Co-localization [6]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name ETS domain-containing protein Elk-1 (ELK1) Interacting Protein Interacting Protein Info
UniProt ID
ELK1_HUMAN 
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [16]
2 Affinity Capture-Western [17]
3 Biochemical Activity [18]
4 Biochemical Activity [19]
5 Biochemical Activity [20]
6 Co-localization [6]
References  Top
REF 1 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 2 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Sci Signal. 2015 Apr 7;8(371):rs3.
REF 3 The protein interaction landscape of the human CMGC kinase group. Cell Rep. 2013 Apr 25;3(4):1306-20.
REF 4 Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. Nat Commun. 2014 Apr 11;5:3650.
REF 5 Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation. Science. 1999 Dec 24;286(5449):2514-7.
REF 6 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 7 MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science. 1998 Sep 11;281(5383):1668-71.
REF 8 Akt regulates vitamin D3-induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling. Eur J Cell Biol. 2009 Feb;88(2):103-15.
REF 9 ERK1b, a 46-kDa ERK isoform that is differentially regulated by MEK. J Biol Chem. 2000 May 26;275(21):15799-808.
REF 10 Properties of MEKs, the kinases that phosphorylate and activate the extracellular signal-regulated kinases. J Biol Chem. 1993 Nov 15;268(32):23933-9.
REF 11 Angiopoietin 2 induces glioma cell invasion by stimulating matrix metalloprotease 2 expression through the alphavbeta1 integrin and focal adhesion kinase signaling pathway. Cancer Res. 2006 Jan 15;66(2):775-83.
REF 12 Characterization of ERK1 activation site mutants and the effect on recognition by MEK1 and MEK2. J Biol Chem. 1996 Feb 23;271(8):4230-5.
REF 13 Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells. J Biol Chem. 1997 Jan 31;272(5):2620-8.
REF 14 p38alpha isoform Mxi2 binds to extracellular signal-regulated kinase 1 and 2 mitogen-activated protein kinase and regulates its nuclear activity by sustaining its phosphorylation levels. Mol Cell Biol. 2003 May;23(9):3079-90.
REF 15 Monitoring protein-protein interactions in mammalian cells by trans-SUMOylation. Biochem J. 2011 Sep 15;438(3):495-503.
REF 16 p44/42 MAP kinase-dependent regulation of catalase by autocrine human growth hormone protects human mammary carcinoma cells from oxidative stress-induced apoptosis. Oncogene. 2005 May 26;24(23):3774-85.
REF 17 Insights into regulation of human Schwann cell proliferation by Erk1/2 via a MEK-independent and p56Lck-dependent pathway from leprosy bacilli. Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9188-93.
REF 18 A novel bile acid-activated vitamin D receptor signaling in human hepatocytes. Mol Endocrinol. 2010 Jun;24(6):1151-64.
REF 19 MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils. Cell Signal. 2003 Nov;15(11):993-1001.
REF 20 Expression of COX-2 in platelet-monocyte interactions occurs via combinatorial regulation involving adhesion and cytokine signaling. J Clin Invest. 2006 Oct;116(10):2727-38.

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