Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T23191 | Target Info | |||
| Target Name | Orphan nuclear receptor DAX-1 (NR0B1) | ||||
| Synonyms | Nuclear receptor subfamily 0 group B member 1; Nuclear receptor DAX-1; DSS-AHC critical region on the X chromosome protein 1; DAX1; AHC | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | NR0B1 | ||||
| Biochemical Class | Nuclear hormone receptor | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Nuclear hormone receptors | [+] 3 Nuclear hormone receptors | + | |||
| Interacting Target Name | Peroxisome proliferator-activated receptor gamma (PPAR-gamma) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3 | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Reconstituted Complex | [2] | |||
| 4 | Yeast two hybrid | [3] | |||
| Interacting Protein Name | Steroidogenic factor 1 (NR5A1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | AD4BP; ELP; FTZ1; FTZF1; POF7; SF.1; SF1; SPGF8; SRXY3 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Reconstituted Complex | [4] | |||
| 2 | Yeast two hybrid | [5] | |||
| 3 | Yeast two hybrid | [6] | |||
| Interacting Target Name | Glucocorticoid receptor (NR3C1) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Nuclear receptor subfamily 3 group C member 1; GRL; GR; Glucocorticoid receptor; Alpha-A | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Protein-Fragment Complementation Assay | [7] | |||
| 2 | Protein-peptide | [8] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Inhibitory effect of PPAR on NR0B1 in tumorigenesis of lung adenocarcinoma. Int J Oncol. 2012 Oct;41(4):1278-84. | ||||
| REF 2 | The orphan nuclear receptor DAX-1 acts as a novel transcriptional corepressor of PPARgamma. Biochem Biophys Res Commun. 2008 May 30;370(2):264-8. | ||||
| REF 3 | Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. Mol Cell Proteomics. 2005 Feb;4(2):205-13. | ||||
| REF 4 | RIP 140 modulates transcription of the steroidogenic acute regulatory protein gene through interactions with both SF-1 and DAX-1. Endocrinology. 2001 Aug;142(8):3570-7. | ||||
| REF 5 | A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226. | ||||
| REF 6 | Widespread macromolecular interaction perturbations in human genetic disorders. Cell. 2015 Apr 23;161(3):647-660. | ||||
| REF 7 | Proteome-scale Binary Interactomics in Human Cells. Mol Cell Proteomics. 2016 Dec;15(12):3624-3639. | ||||
| REF 8 | Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol. Mol Cell Biol. 2008 Mar;28(6):1915-23. | ||||
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