Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T23172 Target Info
Target Name Janus kinase 3 (JAK-3)
Synonyms Tyrosine-protein kinase JAK3; Leukocyte janus kinase; L-JAK
Target Type Successful Target
Gene Name JAK3
Biochemical Class Kinase
UniProt ID
JAK3_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 1 Kinases +
Interacting Target Name ALK tyrosine kinase receptor (ALK) Successful Target Interacting Protein Info
UniProt ID
ALK_HUMAN 
Synonyms CD246; Anaplastic lymphoma kinase
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Signal transducer and activator of transcription 5A (STA5A) Interacting Protein Interacting Protein Info
UniProt ID
STA5A_HUMAN 
Synonyms MGF; STAT5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Yeast two hybrid [4]
References  Top
REF 1 Identification of NPM-ALK interacting proteins by tandem mass spectrometry. Oncogene. 2004 Apr 8;23(15):2617-29.
REF 2 Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death. Oncogene. 2002 Feb 7;21(7):1038-47.
REF 3 Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity. Mol Cell Biol. 2008 Apr;28(7):2271-82.
REF 4 An alternative pathway for STAT activation that is mediated by the direct interaction between JAK and STAT. Oncogene. 1997 Feb 20;14(7):751-61.

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