Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T22496 Target Info
Target Name Huntingtin (HTT)
Synonyms IT15; Huntington disease protein; HD protein; HD
Target Type Clinical trial Target
Gene Name HTT
UniProt ID
HD_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name Valosin-containing protein p97 (VCP) Clinical trial Target Interacting Protein Info
UniProt ID
TERA_HUMAN 
Synonyms Valosin-containing protein; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Reconstituted Complex [2]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name Palmitoyltransferase ZDHHC17 (ZDHHC17) Interacting Protein Interacting Protein Info
UniProt ID
ZDH17_HUMAN 
Synonyms HIP14; HIP3; HYPH
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Yeast two hybrid [4]
Kinases [+] 1 Kinases +
Interacting Protein Name Protein adenylyltransferase FICD (FICD) Interacting Protein Interacting Protein Info
UniProt ID
FICD_HUMAN 
Synonyms HIP13; HYPE; UNQ3041
Evidence Score (E-score) 1 Experimental Evidences +
1 Yeast two hybrid [4]
One-carbon transferases [+] 1 One-carbon transferases +
Interacting Target Name Lysine N-methyltransferase 3A (SETD2) Literature-reported Target Interacting Protein Info
UniProt ID
SETD2_HUMAN 
Synonyms SET2; SET domain-containing protein 2; Protein-lysine N-methyltransferase SETD2; p231HBP; KMT3A; KIAA1732; HYPB; Huntingtin-interacting protein B; Huntingtin-interacting protein 1; Huntingtin yeast partner B; HSPC069; hSET2; Histone-lysine N-methyltransferase SETD2; HIP-1; HIF-1; HIF1
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-crystal Structure [5]
2 Co-localization [5]
3 Yeast two hybrid [4]
Transcription regulators [+] 1 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Co-fractionation [7]
3 Reconstituted Complex [8]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Protein Name Ubiquitin-conjugating enzyme E2 K (UBE2K) Interacting Protein Interacting Protein Info
UniProt ID
UBE2K_HUMAN 
Synonyms E2.25K; HIP2; HYPG; LIG; UBC1
Evidence Score (E-score) 1 Experimental Evidences +
1 Yeast two hybrid [4]
Other proteins [+] 6 Other proteins +
Interacting Protein Name Endophilin-A3 (SH3GL3) Interacting Protein Interacting Protein Info
UniProt ID
SH3G3_HUMAN 
Synonyms CNSA3; EEN.B2; HsT19371; SH3D2C; SH3P13
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [9]
3 Yeast two hybrid [9]
Interacting Protein Name Huntingtin-interacting protein 1 (HIP1) Interacting Protein Interacting Protein Info
UniProt ID
HIP1_HUMAN 
Synonyms HIP.I; ILWEQ
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [10]
2 Yeast two hybrid [10]
Interacting Protein Name Tubulin beta chain (TUBB) Interacting Protein Interacting Protein Info
UniProt ID
TBB5_HUMAN 
Synonyms CDCBM6; M40; OK/SW.cl.56; TUBB1; TUBB5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [11]
2 Affinity Capture-Western [12]
Interacting Protein Name Huntingtin-interacting protein M (HYPM) Interacting Protein Interacting Protein Info
UniProt ID
HYPM_HUMAN 
Synonyms CXorf27; HIP17
Evidence Score (E-score) 1 Experimental Evidences +
1 Yeast two hybrid [4]
Interacting Protein Name Optineurin (OPTN) Interacting Protein Interacting Protein Info
UniProt ID
OPTN_HUMAN 
Synonyms ALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA.INTP
Evidence Score (E-score) 1 Experimental Evidences +
1 Yeast two hybrid [4]
Interacting Protein Name Pre-mRNA-processing factor 40 homolog A (PRPF40A) Interacting Protein Interacting Protein Info
UniProt ID
PR40A_HUMAN 
Synonyms FBP.11; FBP11; FLAF1; FNBP3; HIP.10; HIP10; HYPA; NY.REN.6; Prp40
Evidence Score (E-score) 1 Experimental Evidences +
1 Yeast two hybrid [4]
References  Top
REF 1 VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. PLoS One. 2013;8(1):e55724.
REF 2 A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases. Nat Commun. 2013;4:1816.
REF 3 HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. Hum Mol Genet. 2002 Nov 1;11(23):2815-28.
REF 4 Huntingtin interacts with a family of WW domain proteins. Hum Mol Genet. 1998 Sep;7(9):1463-74.
REF 5 Autoinhibitory structure of the WW domain of HYPB/SETD2 regulates its interaction with the proline-rich region of huntingtin. Structure. 2014 Mar 4;22(3):378-86.
REF 6 Mutant huntingtin represses CBP, but not p300, by binding and protein degradation. Mol Cell Neurosci. 2005 Dec;30(4):560-71.
REF 7 Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity. Science. 2001 Mar 23;291(5512):2423-8.
REF 8 Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila. Nature. 2001 Oct 18;413(6857):739-43.
REF 9 SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates. Mol Cell. 1998 Oct;2(4):427-36.
REF 10 HIP-I: a huntingtin interacting protein isolated by the yeast two-hybrid system. Hum Mol Genet. 1997 Mar;6(3):487-95.
REF 11 Purification of polyglutamine aggregates and identification of elongation factor-1alpha and heat shock protein 84 as aggregate-interacting proteins. J Neurosci. 2002 Nov 1;22(21):9267-77.
REF 12 Perinuclear localization of huntingtin as a consequence of its binding to microtubules through an interaction with beta-tubulin: relevance to Huntington's disease. J Cell Sci. 2002 Mar 1;115(Pt 5):941-8.

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