Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T22285 | Target Info | |||
| Target Name | Glutamate receptor ionotropic NMDA 2A (NMDAR2A) | ||||
| Synonyms | NR2A; NMDA receptor NR2A; N-methyl D-aspartate receptor subtype 2A; HNR2A; Glutamate receptor ionotropic, NMDA 2A; Glutamate [NMDA] receptor subunit epsilon-1; GluN2A | ||||
| Target Type | Successful Target | ||||
| Gene Name | GRIN2A | ||||
| Biochemical Class | Glutamate-gated ion channel | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Auxiliary transporters | [+] 1 Auxiliary transporters | + | |||
| Interacting Protein Name | Disks large homolog 1 (DLG1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | DLGH1; SAP.97; SAP97; dJ1061C18.1.1; hdlg | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Yeast two hybrid | [2] | |||
| Kinases | [+] 1 Kinases | + | |||
| Interacting Target Name | Fyn tyrosine protein kinase (FYN) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Tyrosine-protein kinase Fyn; Src-like kinase; SLK; Proto-oncogene tyrosine-protein kinase Fyn; Proto-oncogene Syn; Proto-oncogene c-Fyn; Fyn Protooncogene Syn; Fyn p59-Fyn | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [3] | |||
| 2 | Affinity Capture-Western | [4] | |||
| 3 | Reconstituted Complex | [4] | |||
| Microtubule-associated | [+] 1 Microtubule-associated | + | |||
| Interacting Target Name | Presynaptic density protein 95 (DLG4) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Synapse-associated protein 90; SAP-90; SAP90; PSD-95; PSD95; Postsynaptic density-95; Postsynaptic density protein 95; Disks large homolog 4; Discs, large homolog 4 | ||||
| Evidence Score (E-score) | 6 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [3] | |||
| 2 | Affinity Capture-Western | [5] | |||
| 3 | Affinity Capture-Western | [6] | |||
| 4 | Far Western | [2] | |||
| 5 | Yeast two hybrid | [7] | |||
| 6 | Yeast two hybrid | [2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | CaMKII-dependent phosphorylation regulates SAP97/NR2A interaction. J Biol Chem. 2003 Nov 7;278(45):44745-52. | ||||
| REF 2 | Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. J Neurosci. 1996 Apr 1;16(7):2157-63. | ||||
| REF 3 | Activation of NMDA receptors and L-type voltage-gated calcium channels mediates enhanced formation of Fyn-PSD95-NR2A complex after transient brain ischemia. Brain Res. 2002 Nov 15;955(1-2):123-32. | ||||
| REF 4 | The effect of transient global ischemia on the interaction of Src and Fyn with the N-methyl-D-aspartate receptor and postsynaptic densities: possible involvement of Src homology 2 domains. J Cereb Blood Flow Metab. 1999 Aug;19(8):880-8. | ||||
| REF 5 | A developmental change in NMDA receptor-associated proteins at hippocampal synapses. J Neurosci. 2000 Feb 1;20(3):1260-71. | ||||
| REF 6 | Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors. J Biol Chem. 2004 Apr 9;279(15):14703-12. | ||||
| REF 7 | Binding of neuroligins to PSD-95. Science. 1997 Sep 5;277(5331):1511-5. | ||||
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