Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T20973 Target Info
Target Name Cyclin-dependent kinase 5 (CDK5)
Synonyms Tau protein kinase II catalytic subunit; TPKII catalytic subunit; Serine/threonine-protein kinase PSSALRE; Serine/threonine protein kinase PSSALRE; Proline-directed protein kinase F(A) (PDPK F(A)); Proline-directed protein kinase 33 kDa subunit; PDPK; Cyclin-dependent-like kinase 5; Cyclin-dependent kinase 5 (CDK5); Cell division protein kinase 5; CDKN5
Target Type Patented-recorded Target
Gene Name CDK5
Biochemical Class Kinase
UniProt ID
CDK5_HUMAN 
Target Interacting Proteins  Top
Beta-transducin repeats [+] 1 Beta-transducin repeats +
Interacting Protein Name Fizzy-related protein homolog (FZR1) Interacting Protein Interacting Protein Info
UniProt ID
FZR1_HUMAN 
Synonyms CDC20C; CDH1; FZR; FZR2; HCDH; HCDH1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Biochemical Activity [2]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Protein Name G1/S-specific cyclin-D2 (CCND2) Interacting Protein Interacting Protein Info
UniProt ID
CCND2_HUMAN 
Synonyms KIAK0002; MPPH3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [4]
3 Affinity Capture-Western [5]
4 Yeast two hybrid [6]
Intermediate filaments [+] 1 Intermediate filaments +
Interacting Target Name Nestin (NES) Literature-reported Target Interacting Protein Info
UniProt ID
NEST_HUMAN 
Synonyms Nbla00170
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Biochemical Activity [8]
Kinases [+] 1 Kinases +
Interacting Target Name CDK5 activator 1 (CDK5R1) Literature-reported Target Interacting Protein Info
UniProt ID
CD5R1_HUMAN 
Synonyms TPKII regulatory subunit; NCK5A; Cyclin-dependent kinase 5 regulatory subunit 1; Cyclindependent kinase 5 regulatory subunit 1; Cyclindependent kinase 5 activator 1, p25; Cyclin-dependent kinase 5 activator 1; Cyclindependent kinase 5 activator 1; CDK5R
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [9]
3 Affinity Capture-Western [10]
4 Affinity Capture-Western [11]
5 Affinity Capture-Western [1]
6 Affinity Capture-Western [12]
7 Co-crystal Structure [10]
8 Reconstituted Complex [13]
Nuclear hormone receptors [+] 1 Nuclear hormone receptors +
Interacting Target Name Peroxisome proliferator-activated receptor gamma (PPAR-gamma) Successful Target Interacting Protein Info
UniProt ID
PPARG_HUMAN 
Synonyms Transcription factor PPAR gamma receptor; PPAR-gamma; PPARgamma; Peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3; NR1C3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [14]
2 Biochemical Activity [15]
Other proteins [+] 2 Other proteins +
Interacting Target Name CDK inhibitor 1B p27Kip1 (CDKN1B) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1B_HUMAN 
Synonyms p27Kip1; KIP1; Cyclin-dependent kinase inhibitor p27; Cyclindependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-MS [16]
2 Affinity Capture-MS [17]
3 Affinity Capture-MS [18]
4 Affinity Capture-MS [4]
5 Affinity Capture-MS [3]
6 Biochemical Activity [19]
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [20]
2 Reconstituted Complex [21]
References  Top
REF 1 Cdk5 levels oscillate during the neuronal cell cycle: Cdh1 ubiquitination triggers proteosome-dependent degradation during S-phase. J Biol Chem. 2012 Jul 27;287(31):25985-94.
REF 2 Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity. EMBO J. 2008 Oct 22;27(20):2736-45.
REF 3 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods. 2013 Apr;10(4):307-14.
REF 4 The protein interaction landscape of the human CMGC kinase group. Cell Rep. 2013 Apr 25;3(4):1306-20.
REF 5 Cyclin D2 interacts with cdk-5 and modulates cellular cdk-5/p35 activity. J Neurochem. 1998 Jan;70(1):335-40.
REF 6 Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 2016 Feb 11;164(4):805-17.
REF 7 A nestin scaffold links Cdk5/p35 signaling to oxidant-induced cell death. EMBO J. 2006 Oct 18;25(20):4808-19.
REF 8 Cdk5 regulates the organization of Nestin and its association with p35. Mol Cell Biol. 2003 Jul;23(14):5090-106.
REF 9 Expression of the neuronal cyclin-dependent kinase 5 activator p35Nck5a in human monocytic cells is associated with differentiation. Blood. 2001 Jun 15;97(12):3763-7.
REF 10 Structure and regulation of the CDK5-p25(nck5a) complex. Mol Cell. 2001 Sep;8(3):657-69.
REF 11 Stabilization and activation of p53 induced by Cdk5 contributes to neuronal cell death. J Cell Sci. 2007 Jul 1;120(Pt 13):2259-71.
REF 12 ODF1 phosphorylation by Cdk5/p35 enhances ODF1-OIP1 interaction. Cell Physiol Biochem. 2007;20(5):311-8.
REF 13 Early protection to stress mediated by CDK-dependent PI3,5P2 signaling from the vacuole/lysosome. J Cell Biol. 2017 Jul 3;216(7):2075-2090.
REF 14 Adipocyte NCoR knockout decreases PPAR phosphorylation and enhances PPAR activity and insulin sensitivity. Cell. 2011 Nov 11;147(4):815-26.
REF 15 GQ-16, a novel peroxisome proliferator-activated receptor (PPAR) ligand, promotes insulin sensitization without weight gain. J Biol Chem. 2012 Aug 10;287(33):28169-79.
REF 16 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 17 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Sci Signal. 2015 Apr 7;8(371):rs3.
REF 18 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.
REF 19 Ubiquitin C-terminal hydrolase L1 (UCH-L1) acts as a novel potentiator of cyclin-dependent kinases to enhance cell proliferation independently of its hydrolase activity. J Biol Chem. 2013 May 3;288(18):12615-26.
REF 20 LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. Nat Commun. 2013;4:1531.
REF 21 Molecular basis for the specificity of p27 toward cyclin-dependent kinases that regulate cell division. J Mol Biol. 2005 Jun 17;349(4):764-73.

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