Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T20761 Target Info
Target Name Vascular endothelial growth factor A (VEGFA)
Synonyms Vascular permeability factor; VPF; VEGF-A; VEGF
Target Type Successful Target
Gene Name VEGFA
Biochemical Class Growth factor
UniProt ID
VEGFA_HUMAN 
Target Interacting Proteins  Top
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Target Name Neuropilin-1 (NRP1) Successful Target Interacting Protein Info
UniProt ID
NRP1_HUMAN 
Synonyms VEGF165R; Vascular endothelial cell growth factor 165 receptor; Platelet-derived endothelial cell growth factor receptor; NRP; Membrane-bound; CD304
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Growth factors [+] 2 Growth factors +
Interacting Target Name Placenta growth factor (PlGF) Successful Target Interacting Protein Info
UniProt ID
PLGF_HUMAN 
Synonyms SHGC-10760; PlGF-2; PLGF; PGFL; D12S1900
Evidence Score (E-score) 2 Experimental Evidences +
1 Co-localization [3]
2 Co-purification [4]
Interacting Target Name Vascular endothelial growth factor B (VEGFB) Successful Target Interacting Protein Info
UniProt ID
VEGFB_HUMAN 
Synonyms VRF; VEGF-related factor; VEGF-B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Co-localization [3]
Kinases [+] 2 Kinases +
Interacting Target Name Vascular endothelial growth factor receptor 2 (KDR) Successful Target Interacting Protein Info
UniProt ID
VGFR2_HUMAN 
Synonyms VEGFR-2; VEGFR2; VEGF-2 receptor; Protein-tyrosine kinase receptor flk-1; Kinase insert domain receptor; FLK-1; FLK1; Fetal liver kinase 1; CD309
Evidence Score (E-score) 3 Experimental Evidences +
1 Biochemical Activity [6]
2 Co-localization [7]
3 Reconstituted Complex [2]
Interacting Target Name Vascular endothelial growth factor receptor 1 (FLT-1) Successful Target Interacting Protein Info
UniProt ID
VGFR1_HUMAN 
Synonyms VEGFR-1; VEGFR1; VEGF-1 receptor; Vascular permeability factor receptor; Tyrosine-protein kinase receptor FLT; Tyrosine-protein kinase FRT; FRT; Fms-like tyrosine kinase 1; FLT
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Reconstituted Complex [8]
References  Top
REF 1 VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors. Oncogene. 2016 Aug 18;35(33):4379-87.
REF 2 Distinct heparin binding sites on VEGF165 and its receptors revealed by their interaction with a non sulfated glycoaminoglycan (NaPaC). Biochim Biophys Acta. 2008 Apr;1780(4):723-32.
REF 3 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 4 Placenta growth factor-1 antagonizes VEGF-induced angiogenesis and tumor growth by the formation of functionally inactive PlGF-1/VEGF heterodimers. Cancer Cell. 2002 Feb;1(1):99-108.
REF 5 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 6 ADAMTS1/METH1 inhibits endothelial cell proliferation by direct binding and sequestration of VEGF165. J Biol Chem. 2003 Jun 27;278(26):23656-65.
REF 7 Receptor protein tyrosine phosphatase beta/zeta is a functional binding partner for vascular endothelial growth factor. Mol Cancer. 2015 Feb 3;14:19.
REF 8 Neuropilin-1 regulates a new VEGF-induced gene, Phactr-1, which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells. Cell Signal. 2012 Jan;24(1):214-23.

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