Target Interacting Protein Information

Content Navigation (  All   None )                                      
Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T20585 Target Info
Target Name Signal transducer and activator of transcription 6 (STAT6)
Synonyms IL-4 Stat
Target Type Literature-reported Target
Gene Name STAT6
Biochemical Class Transcription factor
UniProt ID
STAT6_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Co-crystal Structure [2]
3 Reconstituted Complex [1]
4 Reconstituted Complex [3]
5 Reconstituted Complex [2]
6 Reconstituted Complex [4]
7 Yeast two hybrid [4]
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Co-localization [5]
3 Reconstituted Complex [6]
References  Top
REF 1 Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. J Biol Chem. 2001 Dec 7;276(49):45713-21.
REF 2 Structure of the NCoA-1/SRC-1 PAS-B domain bound to the LXXLL motif of the STAT6 transactivation domain. J Mol Biol. 2004 Feb 13;336(2):319-29.
REF 3 The transcriptional co-activator protein p100 recruits histone acetyltransferase activity to STAT6 and mediates interaction between the CREB-binding protein and STAT6. J Biol Chem. 2005 Apr 15;280(15):14989-96.
REF 4 An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1. J Biol Chem. 2002 Sep 27;277(39):36052-60.
REF 5 Signal transducer and activator of transcription 6 directly regulates human ORMDL3 expression. FEBS J. 2013 May;280(9):2014-26.
REF 6 Cooperation of the transcriptional coactivators CBP and p300 with Stat6. J Interferon Cytokine Res. 1999 Jul;19(7):711-22.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.