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| Target General Information |
Top |
| Target ID |
T19784 |
Target Info
|
| Target Name |
Somatotropin (GH1) |
| Synonyms |
Pituitary growth hormone; Growth hormone 1; Growth hormone; GH-N; GH |
| Target Type |
Clinical trial Target |
| Gene Name |
GH1 |
| Biochemical Class |
Somatotropin/prolactin |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Cytokine receptors |
[+] 1 Cytokine receptors |
+ |
| Interacting Target Name |
Growth hormone receptor (GHR) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Somatotropin receptor; Serum bindingprotein; Growth hormone receptor; GH receptor |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Co-purification |
[1] |
| 2 |
Reconstituted Complex |
[2] |
| 3 |
Reconstituted Complex |
[3] |
| References |
Top |
| REF 1 |
Multimeric growth hormone receptor complexes serve as signaling platforms. J Biol Chem. 2014 Jan 3;289(1):65-73.
|
| REF 2 |
A single arginine residue determines species specificity of the human growth hormone receptor. Proc Natl Acad Sci U S A. 1995 Feb 14;92(4):959-63.
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| REF 3 |
The ubiquitin ligase SCF(betaTrCP) regulates the degradation of the growth hormone receptor. J Biol Chem. 2007 Jul 13;282(28):20475-83.
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