Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T19027 Target Info
Target Name G1/S-specific cyclin-E2 (CCNE2)
Synonyms G1/Sspecific cyclinE2
Target Type Literature-reported Target
Gene Name CCNE2
UniProt ID
CCNE2_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 2 Kinases +
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Reconstituted Complex [4]
Interacting Target Name Cyclin-dependent kinase 3 (CDK3) Clinical trial Target Interacting Protein Info
UniProt ID
CDK3_HUMAN 
Synonyms Cyclindependent kinase 3; Cell division protein kinase 3; CDKN3
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Yeast two hybrid [3]
Other proteins [+] 1 Other proteins +
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [5]
2 Affinity Capture-MS [6]
3 Affinity Capture-Western [2]
4 Reconstituted Complex [4]
References  Top
REF 1 Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers. Mol Cell Biol. 1999 Jan;19(1):612-22.
REF 2 Cyclin E2: a novel CDK2 partner in the late G1 and S phases of the mammalian cell cycle. Oncogene. 1998 Nov 19;17(20):2637-43.
REF 3 Cyclin E2, a novel human G1 cyclin and activating partner of CDK2 and CDK3, is induced by viral oncoproteins. Oncogene. 1998 Nov 26;17(21):2787-98.
REF 4 Self-assembling protein microarrays. Science. 2004 Jul 2;305(5680):86-90.
REF 5 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 6 The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440.

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