Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T18779 | Target Info | |||
| Target Name | Mucin-1 (MUC1) | ||||
| Synonyms | Tumour-associated antigen mucin 1; Tumor-associated mucin; Tumor-associated epithelial membraneantigen; Tumor-associated epithelial membrane antigen; Polymorphic epithelial mucin; Peanut-reactive urinary mucin; PUM; PEMT; PEM; MUC-1; Krebs von den Lungen-6; KL-6; H23AG; Episialin; EMA; Carcinoma-associated mucin; Cancer antigen 15-3; CD227 antigen; CD227; CA 15-3; Breast carcinoma-associated antigen DF3 | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | MUC1 | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Kinases | [+] 4 Kinases | + | |||
| Interacting Target Name | Epidermal growth factor receptor (EGFR) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Affinity Capture-Western | [3] | |||
| 4 | Co-localization | [3] | |||
| Interacting Target Name | Erbb2 tyrosine kinase receptor (HER2) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Tyrosine kinase-type cell surface receptor HER2; Tyrosine kinase receptor ErbB2; Receptor tyrosine-protein kinase erbB-2; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; P185erbB2; NGL; NEU proto-oncogene; NEU; MLN19; MLN 19; Metastatic lymph node gene 19 protein; HER2/neu; HER2 (erbB2/neu); HER-2; Erb2; Epidermal growth factor receptor 2; C-erbB-2 oncoprotein; C-erbB-2; CD340 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [4] | |||
| 2 | Affinity Capture-Western | [1] | |||
| 3 | Co-localization | [4] | |||
| Interacting Target Name | Glycogen synthase kinase-3 beta (GSK-3B) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Serine/threonine-protein kinase GSK3B; GSK-3 beta | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [5] | |||
| 2 | Affinity Capture-Western | [6] | |||
| 3 | Reconstituted Complex | [5] | |||
| Interacting Target Name | Proto-oncogene c-Src (SRC) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Tyrosine kinase (pp60(src)); SRC1; Src tyrosine kinase; Proto-oncogene tyrosine-protein kinase Src; pp60c-src; Pp60(src); P60-Src; C-src TK; C-Src | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [5] | |||
| 2 | Reconstituted Complex | [5] | |||
| Other proteins | [+] 1 Other proteins | + | |||
| Interacting Target Name | Beta-catenin (CTNNB1) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Wnt/beta-catenin signaling pathway; PRO2286; OK/SW-cl.35; CTNNB; Catenin beta-1 | ||||
| Evidence Score (E-score) | 7 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [7] | |||
| 2 | Affinity Capture-Western | [6] | |||
| 3 | Affinity Capture-Western | [2] | |||
| 4 | Affinity Capture-Western | [8] | |||
| 5 | Reconstituted Complex | [7] | |||
| 6 | Reconstituted Complex | [6] | |||
| 7 | Reconstituted Complex | [9] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland. J Biol Chem. 2001 Apr 20;276(16):13057-64. | ||||
| REF 2 | The epidermal growth factor receptor regulates interaction of the human DF3/MUC1 carcinoma antigen with c-Src and beta-catenin. J Biol Chem. 2001 Sep 21;276(38):35239-42. | ||||
| REF 3 | Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells. Oncogene. 2011 Jun 2;30(22):2514-25. | ||||
| REF 4 | Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein. Mol Cancer Res. 2003 Aug;1(10):765-75. | ||||
| REF 5 | The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin. J Biol Chem. 2001 Mar 2;276(9):6061-4. | ||||
| REF 6 | Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin. Mol Cell Biol. 1998 Dec;18(12):7216-24. | ||||
| REF 7 | Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion. J Biol Chem. 1997 May 9;272(19):12492-4. | ||||
| REF 8 | Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling. J Biol Chem. 2002 May 17;277(20):17616-22. | ||||
| REF 9 | DF3/MUC1 signaling in multiple myeloma cells is regulated by interleukin-7. Cancer Biol Ther. 2003 Mar-Apr;2(2):187-93. | ||||
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