Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T18639 Target Info
Target Name Heparin-binding growth factor 1 (FGF1)
Synonyms HBGF-1; Fibroblast growth factor 1; FGFA; FGF-1; Endothelial cell growth factor; ECGF-beta; ECGF; Beta-endothelial cell growth factor; Acidic fibroblast growth factor; AFGF
Target Type Clinical trial Target
Gene Name FGF1
Biochemical Class Growth factor
UniProt ID
FGF1_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 3 Kinases +
Interacting Target Name Fibroblast growth factor receptor 1 (FGFR1) Successful Target Interacting Protein Info
UniProt ID
FGFR1_HUMAN 
Synonyms N-sam; HBGFR; Fms-like tyrosine kinase 2; FLT-2; FLT2; FLG; FGFR-1; FGFBR; c-fgr; CEK; CD331 antigen; CD331; bFGF-R-1; bFGF-R; BFGFR; Basic fibroblast growth factor receptor 1
Evidence Score (E-score) 6 Experimental Evidences +
1 Co-crystal Structure [1]
2 Co-localization [2]
3 Reconstituted Complex [3]
4 Reconstituted Complex [4]
5 Reconstituted Complex [5]
6 Reconstituted Complex [6]
Interacting Target Name Fibroblast growth factor receptor 2 (FGFR2) Successful Target Interacting Protein Info
UniProt ID
FGFR2_HUMAN 
Synonyms K-sam; KSAM; KGFR; Keratinocyte growth factor receptor 2; Keratinocyte growth factor receptor; FGFR-2; FGF-2 receptor; CD332; BEK
Evidence Score (E-score) 4 Experimental Evidences +
1 Co-crystal Structure [7]
2 Co-crystal Structure [8]
3 Reconstituted Complex [3]
4 Reconstituted Complex [4]
Interacting Target Name Fibroblast growth factor receptor 4 (FGFR4) Clinical trial Target Interacting Protein Info
UniProt ID
FGFR4_HUMAN 
Synonyms TKF; JTK2; FGFR-4; CD334
Evidence Score (E-score) 4 Experimental Evidences +
1 Co-localization [2]
2 Reconstituted Complex [9]
3 Reconstituted Complex [4]
4 Reconstituted Complex [10]
References  Top
REF 1 Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization. Mol Cell. 2000 Sep;6(3):743-50.
REF 2 Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network. J Proteome Res. 2014 Dec 5;13(12):5339-46.
REF 3 Nectin-1 binds and signals through the fibroblast growth factor receptor. J Biol Chem. 2012 Oct 26;287(44):37420-33.
REF 4 Differential effects of heparin saccharides on the formation of specific fibroblast growth factor (FGF) and FGF receptor complexes. J Biol Chem. 2002 Jan 25;277(4):2444-53.
REF 5 Control of fibroblast growth factor receptor kinase signal transduction by heterodimerization of combinatorial splice variants. Mol Cell Biol. 1993 Jul;13(7):3907-18.
REF 6 A functional fibroblast growth factor-1 immunoglobulin fusion protein. J Biol Chem. 1998 Jun 19;273(25):15811-7.
REF 7 Structural interactions of fibroblast growth factor receptor with its ligands. Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):49-54.
REF 8 Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin. Nature. 2000 Oct 26;407(6807):1029-34.
REF 9 Production and characterization of the extracellular domain of recombinant human fibroblast growth factor receptor 4. Int J Biochem Cell Biol. 2000 May;32(5):489-97.
REF 10 Specificity for fibroblast growth factors determined by heparan sulfate in a binary complex with the receptor kinase. J Biol Chem. 1999 May 28;274(22):15947-52.

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