Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T17569 Target Info
Target Name Voltage-gated potassium channel Kv1.5 (KCNA5)
Synonyms Voltage-gatedpotassium channel subunit Kv1.5; Voltage-gated potassium channel subunit Kv1.5; Voltage-gated potassium channel HK2; Potassium voltage-gated channel subfamily A member 5; Potassium channel Kv1.5; HPCN1; HK2; 02-Sensitive Potassium Channel Kv1.5
Target Type Successful Target
Gene Name KCNA5
Biochemical Class Voltage-gated ion channel
UniProt ID
KCNA5_HUMAN 
Target Interacting Proteins  Top
Alpha-type channels [+] 1 Alpha-type channels +
Interacting Target Name Voltage-gated potassium channel Kv1.3 (KCNA3) Clinical trial Target Interacting Protein Info
UniProt ID
KCNA3_HUMAN 
Synonyms Voltage-gated potassium channel subunit Kv1.3; Voltage-gated Kv1.3 K(+) channel; Voltage-gated K(+) channel Kv1.3; Potassium channel Kv1.3; KCNA3; HuKIII; HPCN3; HLK3; HGK5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name Alpha-actinin-2 (ACTN2) Interacting Protein Interacting Protein Info
UniProt ID
ACTN2_HUMAN 
Synonyms CMD1AA
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
3 Yeast two hybrid [5]
Microtubule-associated [+] 1 Microtubule-associated +
Interacting Target Name Presynaptic density protein 95 (DLG4) Clinical trial Target Interacting Protein Info
UniProt ID
DLG4_HUMAN 
Synonyms Synapse-associated protein 90; SAP-90; SAP90; PSD-95; PSD95; Postsynaptic density-95; Postsynaptic density protein 95; Disks large homolog 4; Discs, large homolog 4
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [6]
3 Yeast two hybrid [6]
Other proteins [+] 2 Other proteins +
Interacting Target Name Skeletal muscle LIM-protein 1 (FHL1) Literature-reported Target Interacting Protein Info
UniProt ID
FHL1_HUMAN 
Synonyms SLIM1; SLIM; Skeletal muscle LIMprotein 1; Four and a half LIM domains protein 1; FHL1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [8]
3 Affinity Capture-Western [7]
Interacting Protein Name Voltage-gated potassium channel subunit beta-2 (KCNAB2) Interacting Protein Interacting Protein Info
UniProt ID
KCAB2_HUMAN 
Synonyms AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2; KCNA2B; KV.BETA.2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [9]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 Kv1.5 association modifies Kv1.3 traffic and membrane localization. J Biol Chem. 2008 Mar 28;283(13):8756-64.
REF 3 alpha-actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells. FEBS Lett. 2000 May 12;473(2):188-94.
REF 4 A discrete amino terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of alpha-actinin-2. FEBS Lett. 2001 Jun 1;498(1):87-92.
REF 5 SAP97 increases Kv1.5 currents through an indirect N-terminal mechanism. FEBS Lett. 2003 Jul 17;547(1-3):205-11.
REF 6 N-terminal PDZ-binding domain in Kv1 potassium channels. FEBS Lett. 2002 Nov 20;531(3):529-37.
REF 7 Four and a half LIM protein 1: a partner for KCNA5 in human atrium. Cardiovasc Res. 2008 Jun 1;78(3):449-57.
REF 8 Four and a half LIM protein 1C (FHL1C): a binding partner for voltage-gated potassium channel K(v1.5). PLoS One. 2011;6(10):e26524.
REF 9 Incretin-stimulated interaction between -cell Kv1.5 and Kv2 channel proteins involves acetylation/deacetylation by CBP/SirT1. Biochem J. 2013 Apr 15;451(2):227-34.

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