Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T16347 Target Info
Target Name Protein-tyrosine phosphatase 1B (PTP1B)
Synonyms Tyrosine-protein phosphatase non-receptor type 1; PTP-1B
Target Type Clinical trial Target
Gene Name PTPN1
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
PTN1_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name Growth factor receptor-bound protein 2 (GRB2) Interacting Protein Interacting Protein Info
UniProt ID
GRB2_HUMAN 
Synonyms SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Kinases [+] 3 Kinases +
Interacting Target Name Epidermal growth factor receptor (EGFR) Successful Target Interacting Protein Info
UniProt ID
EGFR_HUMAN 
Synonyms Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Luminescence [3]
2 Biochemical Activity [4]
3 Co-crystal Structure [5]
4 Protein-Fragment Complementation Assay [3]
5 Reconstituted Complex [6]
6 Yeast two hybrid [7]
Interacting Target Name Janus kinase 2 (JAK-2) Successful Target Interacting Protein Info
UniProt ID
JAK2_HUMAN 
Synonyms Tyrosine-protein kinase JAK2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Biochemical Activity [9]
Interacting Target Name BDNF/NT-3 growth factors receptor (TrkB) Successful Target Interacting Protein Info
UniProt ID
NTRK2_HUMAN 
Synonyms Tropomyosin-related kinase B; TrkB tyrosine kinase; Trk-B; TRKB; Neurotrophic tyrosine kinase receptor type 2; GP145-TrkB
Evidence Score (E-score) 2 Experimental Evidences +
1 Protein-peptide [10]
2 Reconstituted Complex [11]
References  Top
REF 1 Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. Mol Cell Proteomics. 2016 Sep;15(9):3030-44.
REF 2 Tyrosine dephosphorylation and deactivation of insulin receptor substrate-1 by protein-tyrosine phosphatase 1B. Possible facilitation by the formation of a ternary complex with the Grb2 adaptor protein. J Biol Chem. 2000 Feb 11;275(6):4283-9.
REF 3 The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells. Nat Methods. 2014 May;11(5):585-92.
REF 4 Determinants of substrate recognition in the protein-tyrosine phosphatase, PTP1. J Biol Chem. 1996 Mar 8;271(10):5386-92.
REF 5 Structural basis of plasticity in protein tyrosine phosphatase 1B substrate recognition. Biochemistry. 2000 Jul 18;39(28):8171-9.
REF 6 Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B. J Biol Chem. 1993 Nov 5;268(31):23634-9.
REF 7 In silico prediction of physical protein interactions and characterization of interactome orphans. Nat Methods. 2015 Jan;12(1):79-84.
REF 8 TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B. J Biol Chem. 2001 Dec 21;276(51):47771-4.
REF 9 Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling. J Mol Endocrinol. 2005 Apr;34(2):339-51.
REF 10 The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities. Protein Sci. 2002 Oct;11(10):2326-34.
REF 11 Protein-tyrosine phosphatase 1B (PTP1B) is a novel regulator of central brain-derived neurotrophic factor and tropomyosin receptor kinase B (TrkB) signaling. J Biol Chem. 2014 Nov 14;289(46):31682-92.

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