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| Target General Information |
Top |
| Target ID |
T16263 |
Target Info
|
| Target Name |
T-cell-specific protein RANTES (CCL5) |
| Synonyms |
Tcellspecific protein RANTES; TCP228; T cellspecific protein P228; T cell-specific protein P228; Smallinducible cytokine A5; Small-inducible cytokine A5; SISdelta; SIS-delta; SCYA5; RANTES(468); Eosinophil chemotactic cytokine; EoCP; D17S136E; CC motif chemokine 5; C-C motif chemokine 5 |
| Target Type |
Clinical trial Target |
| Gene Name |
CCL5 |
| Biochemical Class |
Cytokine: CC chemokine |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| G-protein-coupled receptors |
[+] 1 G-protein-coupled receptors |
+ |
| Interacting Target Name |
C-C chemokine receptor type 5 (CCR5) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
HIV-1 fusion co-receptor; HIV-1 fusion coreceptor; CMKBR5; CHEMR13; Chemokine receptor CCR5; CD195 antigen; CD195; CCR-5; CC-CKR-5; C-C CKR-5; C-C chemokine receptor type 5 |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Reconstituted Complex |
[2] |
| 3 |
Reconstituted Complex |
[3] |
| References |
Top |
| REF 1 |
Interaction of RANTES with syndecan-1 and syndecan-4 expressed by human primary macrophages. Biochim Biophys Acta. 2003 Oct 31;1617(1-2):80-8.
|
| REF 2 |
Diverging binding capacities of natural LD78beta isoforms of macrophage inflammatory protein-1alpha to the CC chemokine receptors 1, 3 and 5 affect their anti-HIV-1 activity and chemotactic potencies for neutrophils and eosinophils. Eur J Immunol. 2001 Jul;31(7):2170-8.
|
| REF 3 |
The BBXB motif of RANTES is the principal site for heparin binding and controls receptor selectivity. J Biol Chem. 2001 Apr 6;276(14):10620-6.
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