Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15023 | Target Info | |||
| Target Name | Neuropilin-1 (NRP1) | ||||
| Synonyms | Vascular endothelial cell growth factor 165 receptor; VEGF165R; Platelet-derived endothelial cell growth factor receptor; NRP; Membrane-bound; CD304 | ||||
| Target Type | Successful Target | ||||
| Gene Name | NRP1 | ||||
| Biochemical Class | Neuropilin and tolloid-like | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Growth factors | [+] 1 Growth factors | + | |||
| Interacting Target Name | Vascular endothelial growth factor A (VEGFA) | Successful Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | VPF; VEGF-A; VEGF; Vascular permeability factor; Vascular endothelial growth factor A | ||||
| Evidence Score (E-score) | 7 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Co-crystal Structure | [3] | |||
| 4 | Reconstituted Complex | [4] | |||
| 5 | Reconstituted Complex | [1] | |||
| 6 | Reconstituted Complex | [3] | |||
| 7 | Reconstituted Complex | [5] | |||
| Kinases | [+] 2 Kinases | + | |||
| Interacting Target Name | TGF-beta receptor type I (TGFBR1) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Type I TGFbeta receptor kinase; Transforming growth factor-beta receptor type I; TGFR-1; TGF-beta type I receptor; TGF-beta receptor type-1; TbetaR-I; TbetaRI; SKR4; Serine/threonine-protein kinase receptor R4; ALK-5; ALK5; Activin receptor-like kinase 5; Activin A receptor type II-like protein kinase of 53kD | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [6] | |||
| 2 | Reconstituted Complex | [7] | |||
| Interacting Target Name | TGF-beta receptor type II (TGFBR2) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Transforminggrowth factor-beta receptor type II; Transforming growth factor-beta receptor type II; TGFR-2; TGF-beta type II receptor; TGF-beta receptor type-2; TbetaR-II | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [6] | |||
| 2 | Reconstituted Complex | [7] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor. Cell. 1998 Mar 20;92(6):735-45. | ||||
| REF 2 | VEGF-A acts via neuropilin-1 to enhance epidermal cancer stem cell survival and formation of aggressive and highly vascularized tumors. Oncogene. 2016 Aug 18;35(33):4379-87. | ||||
| REF 3 | Structural basis for selective vascular endothelial growth factor-A (VEGF-A) binding to neuropilin-1. J Biol Chem. 2012 Mar 30;287(14):11082-9. | ||||
| REF 4 | Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain. J Biol Chem. 2002 Jul 5;277(27):24818-25. | ||||
| REF 5 | Sugar-based peptidomimetics as potential inhibitors of the vascular endothelium growth factor binding to neuropilin-1. Bioorg Med Chem. 2010 May 1;18(9):3285-98. | ||||
| REF 6 | Neuropilin-1 mediates divergent R-Smad signaling and the myofibroblast phenotype. J Biol Chem. 2010 Oct 8;285(41):31840-8. | ||||
| REF 7 | Neuropilin-1 exerts co-receptor function for TGF-beta-1 on the membrane of cancer cells and enhances responses to both latent and active TGF-beta. Carcinogenesis. 2011 Apr;32(4):613-21. | ||||
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