Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T14875 Target Info
Target Name Ubiquitin carboxyl-terminal hydrolase 14 (USP14)
Synonyms Ubiquitin-specific-processing protease 14; Ubiquitin thioesterase 14; TGT; Deubiquitinating enzyme 14
Target Type Preclinical Target
Gene Name USP14
Biochemical Class Peptidase
UniProt ID
UBP14_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Protein Name Proteasome 26S subunit ATPase 3 (PSMC3) Interacting Protein Interacting Protein Info
UniProt ID
PRS6A_HUMAN 
Synonyms TBP1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Interacting Protein Name Proteasome 26S subunit ATPase 5 (PSMC5) Interacting Protein Interacting Protein Info
UniProt ID
PRS8_HUMAN 
Synonyms S8; SUG.1; SUG1; TBP10; TRIP1; p45; p45/SUG
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Acyltransferases [+] 1 Acyltransferases +
Interacting Target Name Renal carcinoma antigen NY-REN-54 (UBE3A) Literature-reported Target Interacting Protein Info
UniProt ID
UBE3A_HUMAN 
Synonyms Ubiquitin-protein ligase E3A; Oncogenic protein-associated protein E6-AP; Human papillomavirus E6-associated protein; HPVE6A; HECT-type ubiquitin transferase E3A; EPVE6AP; E6AP ubiquitin-protein ligase; E6AP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Co-fractionation [4]
Peptidases [+] 2 Peptidases +
Interacting Protein Name Proteasome 26S subunit non-ATPase 7 (PSMD7) Interacting Protein Interacting Protein Info
UniProt ID
PSMD7_HUMAN 
Synonyms MOV34; P40; Rpn8; S12
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Co-fractionation [2]
Interacting Protein Name Proteasome 26S subunit non-ATPase 14 (PSMD14) Interacting Protein Interacting Protein Info
UniProt ID
PSDE_HUMAN 
Synonyms PAD1; POH1; RPN11
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Proteasome components [+] 5 Proteasome components +
Interacting Protein Name Tumor necrosis factor type 1 receptor-associated protein 2 (PSMD2) Interacting Protein Interacting Protein Info
UniProt ID
PSMD2_HUMAN 
Synonyms P97; RPN1; S2; TRAP2
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-Western [6]
4 Affinity Capture-Western [5]
Interacting Protein Name Proteasome 26S subunit non-ATPase 1 (PSMD1) Interacting Protein Interacting Protein Info
UniProt ID
PSMD1_HUMAN 
Synonyms P112; Rpn2; S1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [5]
3 Co-fractionation [2]
Interacting Protein Name Proteasome 26S subunit non-ATPase 11 (PSMD11) Interacting Protein Interacting Protein Info
UniProt ID
PSD11_HUMAN 
Synonyms Rpn6; S9; p44.5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Interacting Protein Name Proteasome 26S subunit non-ATPase 12 (PSMD12) Interacting Protein Interacting Protein Info
UniProt ID
PSD12_HUMAN 
Synonyms Rpn5; p55
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Interacting Protein Name Proteasome 26S subunit non-ATPase 13 (PSMD13) Interacting Protein Interacting Protein Info
UniProt ID
PSD13_HUMAN 
Synonyms HSPC027; Rpn9; S11; p40.5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Co-fractionation [2]
Ubiquitin related proteins [+] 1 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [7]
2 Protein-peptide [8]
References  Top
REF 1 Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.
REF 2 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 3 Network Analysis of UBE3A/E6AP-Associated Proteins Provides Connections to Several Distinct Cellular Processes. J Mol Biol. 2018 Mar 30;430(7):1024-1050.
REF 4 A census of human soluble protein complexes. Cell. 2012 Aug 31;150(5):1068-81.
REF 5 TRIM11 activates the proteasome and promotes overall protein degradation by regulating USP14. Nat Commun. 2018 Mar 26;9(1):1223.
REF 6 Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1. Hum Mol Genet. 2014 Nov 15;23(22):5928-39.
REF 7 Non-hydrolyzable Diubiquitin Probes Reveal Linkage-Specific Reactivity of Deubiquitylating Enzymes Mediated by S2 Pockets. Cell Chem Biol. 2016 Apr 21;23(4):472-82.
REF 8 A strategy for modulation of enzymes in the ubiquitin system. Science. 2013 Feb 1;339(6119):590-5.

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