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| Target General Information |
Top |
| Target ID |
T14110 |
Target Info
|
| Target Name |
Beta-klotho (KLB) |
| Synonyms |
Klotho beta-like protein; BetaKlotho; BKL |
| Target Type |
Clinical trial Target |
| Gene Name |
KLB |
| Biochemical Class |
Glycosylase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Fibroblast growth factor receptor 1 (FGFR1) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
N-sam; HBGFR; Fms-like tyrosine kinase 2; FLT-2; FLT2; FLG; FGFR-1; FGFBR; c-fgr; CEK; CD331 antigen; CD331; bFGF-R-1; bFGF-R; BFGFR; Basic fibroblast growth factor receptor 1 |
| Evidence Score (E-score) |
2 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Fluorescence Resonance Energy Transfer |
[2] |
| References |
Top |
| REF 1 |
Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21. J Biol Chem. 2007 Sep 14;282(37):26687-95.
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| REF 2 |
Unliganded fibroblast growth factor receptor 1 forms density-independent dimers. J Biol Chem. 2015 Oct 2;290(40):24166-77.
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