Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T13928 | Target Info | |||
| Target Name | Deneddylase-1 (SENP8) | ||||
| Synonyms | Sentrin/SUMO-specific protease SENP8; Sentrin-specific protease 8; Protease, cysteine 2; PRSC2; NEDP1; NEDD8-specific protease 1; FKSG8; DEN1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SENP8 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Cullins | [+] 1 Cullins | + | |||
| Interacting Protein Name | Cullin-1 (CUL1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Biochemical Activity | [2] | |||
| 3 | Biochemical Activity | [1] | |||
| Ubiquitin related proteins | [+] 1 Ubiquitin related proteins | + | |||
| Interacting Target Name | Ubiquitin-like protein Nedd8 (NEDD8) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Ubiquitin-like protein Nedd8; Neural precursor cell expressed developmentally down-regulated protein 8; Neddylin; NEDD-8 | ||||
| Evidence Score (E-score) | 5 Experimental Evidences | + | |||
| 1 | Biochemical Activity | [3] | |||
| 2 | Biochemical Activity | [4] | |||
| 3 | Co-crystal Structure | [4] | |||
| 4 | Co-crystal Structure | [5] | |||
| 5 | Reconstituted Complex | [6] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. Nat Cell Biol. 2010 Apr;12(4):351-61. | ||||
| REF 2 | Control of multicellular development by the physically interacting deneddylases DEN1/DenA and COP9 signalosome. PLoS Genet. 2013;9(2):e1003275. | ||||
| REF 3 | A time-resolved fluorescence resonance energy transfer-based assay for DEN1 peptidase activity. Anal Biochem. 2009 Jul 1;390(1):85-7. | ||||
| REF 4 | Structural basis of NEDD8 ubiquitin discrimination by the deNEDDylating enzyme NEDP1. EMBO J. 2005 Apr 6;24(7):1341-51. | ||||
| REF 5 | Structure of a complex between Nedd8 and the Ulp/Senp protease family member Den1. J Mol Biol. 2005 Jan 7;345(1):141-51. | ||||
| REF 6 | DEN1 is a dual function protease capable of processing the C terminus of Nedd8 and deconjugating hyper-neddylated CUL1. J Biol Chem. 2003 Aug 1;278(31):28882-91. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.