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| Target General Information |
Top |
| Target ID |
T13902 |
Target Info
|
| Target Name |
Liver receptor homolog-1 (NR5A2) |
| Synonyms |
LRH1; CYP7A promoterbinding factor; B1binding factor; Alpha1fetoprotein transcription factor |
| Target Type |
Literature-reported Target |
| Gene Name |
NR5A2 |
| Biochemical Class |
Nuclear hormone receptor |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Nuclear hormone receptors |
[+] 1 Nuclear hormone receptors |
+ |
| Interacting Target Name |
Orphan nuclear receptor SHP (NR0B2) |
Literature-reported Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Small heterodimer partner; SHP; Short heterodimer partner; Nuclear receptor subfamily 0 group B member 2 |
| Evidence Score (E-score) |
4 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Reconstituted Complex |
[2] |
| 3 |
Reconstituted Complex |
[3] |
| 4 |
Reconstituted Complex |
[4] |
| References |
Top |
| REF 1 |
Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation. Nucleic Acids Res. 2010 Aug;38(14):4607-19.
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| REF 2 |
The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity. Mol Endocrinol. 2002 Sep;16(9):2065-76.
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| REF 3 |
Novel polymorphisms of nuclear receptor SHP associated with functional and structural changes. J Biol Chem. 2010 Aug 6;285(32):24871-81.
|
| REF 4 |
Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes. Mol Endocrinol. 2011 Jul;25(7):1159-69.
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