Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T13616 Target Info
Target Name Integrin-linked protein kinase 1 (ILK)
Synonyms P59ILK; Integrin-linked protein kinase; Integrin-linked kinase; ILK2; ILK1; ILK-2; ILK-1; Beta-integrin-linked kinase; 59 kDa serine/threonine-protein kinase; 59 kDa serine/threonine protein kinase
Target Type Patented-recorded Target
Gene Name ILK
Biochemical Class Kinase
UniProt ID
ILK_HUMAN 
Target Interacting Proteins  Top
Adapter proteins [+] 3 Adapter proteins +
Interacting Protein Name Beta-parvin (PARVB) Interacting Protein Interacting Protein Info
UniProt ID
PARVB_HUMAN 
Synonyms CGI.56
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [3]
4 Affinity Capture-MS [4]
5 Co-fractionation [5]
Interacting Protein Name LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) Interacting Protein Interacting Protein Info
UniProt ID
LIMS1_HUMAN 
Synonyms PINCH; PINCH.1; PINCH1
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [6]
3 Affinity Capture-MS [4]
4 Affinity Capture-Western [7]
5 Yeast two hybrid [8]
Interacting Protein Name LIM and senescent cell antigen-like-containing domain protein 2 (LIMS2) Interacting Protein Interacting Protein Info
UniProt ID
LIMS2_HUMAN 
Synonyms PINCH.2; PINCH2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [4]
2 Affinity Capture-Western [7]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Protein Name Heat shock protein 105 kDa (HSPH1) Interacting Protein Interacting Protein Info
UniProt ID
HS105_HUMAN 
Synonyms HSP105; HSP105A; HSP105B; NY.CO.25
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [6]
2 Co-fractionation [9]
Kinases [+] 1 Kinases +
Interacting Target Name RAC-alpha serine/threonine-protein kinase (AKT1) Successful Target Interacting Protein Info
UniProt ID
AKT1_HUMAN 
Synonyms RAC-PK-alpha; RAC; Proto-oncogene c-Akt; Protein kinase B alpha; Protein kinase B; PKB alpha; PKB
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [10]
2 Affinity Capture-Western [11]
3 Biochemical Activity [12]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Alpha-parvin (PARVA) Interacting Protein Interacting Protein Info
UniProt ID
PARVA_HUMAN 
Synonyms CH.ILKBP; MXRA2
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-MS [6]
3 Affinity Capture-MS [4]
4 Co-fractionation [5]
5 Yeast two hybrid [13]
6 Yeast two hybrid [14]
7 Yeast two hybrid [15]
References  Top
REF 1 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 2 Large-scale mapping of human protein-protein interactions by mass spectrometry. Mol Syst Biol. 2007;3:89.
REF 3 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 4 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods. 2013 Apr;10(4):307-14.
REF 5 Panorama of ancient metazoan macromolecular complexes. Nature. 2015 Sep 17;525(7569):339-44.
REF 6 Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. Sci Signal. 2015 Apr 7;8(371):rs3.
REF 7 Characterization of PINCH-2, a new focal adhesion protein that regulates the PINCH-1-ILK interaction, cell spreading, and migration. J Biol Chem. 2002 Oct 11;277(41):38328-38.
REF 8 The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. Mol Cell Biol. 1999 Mar;19(3):2425-34.
REF 9 A high-throughput approach for measuring temporal changes in the interactome. Nat Methods. 2012 Sep;9(9):907-9.
REF 10 Protein kinase B is regulated in platelets by the collagen receptor glycoprotein VI. J Biol Chem. 2002 Apr 12;277(15):12874-8.
REF 11 Rictor and integrin-linked kinase interact and regulate Akt phosphorylation and cancer cell survival. Cancer Res. 2008 Mar 15;68(6):1618-24.
REF 12 Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase. Proc Natl Acad Sci U S A. 1998 Sep 15;95(19):11211-6.
REF 13 Next-generation sequencing to generate interactome datasets. Nat Methods. 2011 Jun;8(6):478-80.
REF 14 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 15 Towards a proteome-scale map of the human protein-protein interaction network. Nature. 2005 Oct 20;437(7062):1173-8.

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