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| Target General Information |
Top |
| Target ID |
T13348 |
Target Info
|
| Target Name |
AP endonuclease 1 (APEX1) |
| Synonyms |
Redox factor-1; REF1; REF-1; HAP1; DNA-(apurinic or apyrimidinic site) lyase; Apurinic-apyrimidinic endonuclease 1; APX; APEX nuclease; APEX; APEN; APE1; APE-1; APE |
| Target Type |
Clinical trial Target |
| Gene Name |
APEX1 |
| Biochemical Class |
Alpha-carbonic anhydrase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Acyltransferases |
[+] 1 Acyltransferases |
+ |
| Interacting Target Name |
Histone acetyltransferase p300 (EP300) |
Clinical trial Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300 |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-Western |
[1] |
| 2 |
Biochemical Activity |
[2] |
| 3 |
Reconstituted Complex |
[1] |
| Kinases |
[+] 1 Kinases |
+ |
| Interacting Target Name |
Epidermal growth factor receptor (EGFR) |
Successful Target |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
Epidermal growth factor receptor variant III; Proto-oncogene c-ErbB-1 variant III; Receptor tyrosine-protein kinase erbB-1 variant III; EGFR variant III; ERBB variant III; ERBB1 variant III; HER1 variant III |
| Evidence Score (E-score) |
1 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[3] |
| References |
Top |
| REF 1 |
Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1. Oncogene. 2011 Jan 27;30(4):482-93.
|
| REF 2 |
Role of acetylated human AP-endonuclease (APE1/Ref-1) in regulation of the parathyroid hormone gene. EMBO J. 2003 Dec 1;22(23):6299-309.
|
| REF 3 |
Importance of EGFR/ERCC1 interaction following radiation-induced DNA damage. Clin Cancer Res. 2014 Jul 1;20(13):3496-506.
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