Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T12966 Target Info
Target Name Troponin C (TN-C)
Synonyms Troponin C, slow skeletal and cardiac muscles; TNNC
Target Type Successful Target
Gene Name TNNC1
UniProt ID
TNNC1_HUMAN 
Target Interacting Proteins  Top
Other proteins [+] 2 Other proteins +
Interacting Target Name Cardiac troponin I (TNNI3) Literature-reported Target Interacting Protein Info
UniProt ID
TNNI3_HUMAN 
Synonyms TNNI3; Cardiac troponin I
Evidence Score (E-score) 4 Experimental Evidences +
1 Co-crystal Structure [1]
2 Protein-peptide [2]
3 Reconstituted Complex [3]
4 Reconstituted Complex [4]
Interacting Protein Name Troponin I, slow skeletal muscle (TNNI1) Interacting Protein Interacting Protein Info
UniProt ID
TNNI1_HUMAN 
Synonyms SSTNI; TNN1
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-crystal Structure [5]
2 Reconstituted Complex [6]
3 Yeast two hybrid [7]
References  Top
REF 1 Structure of the regulatory N-domain of human cardiac troponin C in complex with human cardiac troponin I147-163 and bepridil. J Biol Chem. 2002 Aug 23;277(34):31124-33.
REF 2 Kinetic studies of calcium and cardiac troponin I peptide binding to human cardiac troponin C using NMR spectroscopy. Eur Biophys J. 2002 Jul;31(4):245-56.
REF 3 A cross-linking study of the N-terminal extension of human cardiac troponin I. Biochemistry. 2003 Sep 2;42(34):10324-32.
REF 4 Overexpression of human cardiac troponin-I and troponin-C in Escherichia coli and their purification and characterisation. Two point mutations allow high-level expression of troponin-I. Eur J Biochem. 1994 Nov 1;225(3):1195-201.
REF 5 Tryptophan mutants of cardiac troponin C: 3D structure, troponin I affinity, and in situ activity. Biochemistry. 2008 Jan 15;47(2):597-606.
REF 6 Effects of T142 phosphorylation and mutation R145G on the interaction of the inhibitory region of human cardiac troponin I with the C-domain of human cardiac troponin C. Biochemistry. 2002 Jun 11;41(23):7267-74.
REF 7 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.

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