Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T12837 Target Info
Target Name Histone-arginine methyltransferase CARM1 (CARM1)
Synonyms Protein arginine N-methyltransferase 4; PRMT4; Histonearginine methyltransferase CARM1; Coactivatorassociated arginine methyltransferase 1; Coactivator-associated arginine methyltransferase 1
Target Type Literature-reported Target
Gene Name CARM1
Biochemical Class Methyltransferase
UniProt ID
CARM1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 3 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Biochemical Activity [4]
5 Biochemical Activity [1]
6 Biochemical Activity [5]
7 Reconstituted Complex [1]
8 Reconstituted Complex [3]
9 Yeast two hybrid [1]
10 Yeast two hybrid [6]
Interacting Target Name Nuclear receptor coactivator 3 (NCOA3) Literature-reported Target Interacting Protein Info
UniProt ID
NCOA3_HUMAN 
Synonyms TRAM-1; TRAM1; Thyroid hormone receptor activator molecule 1; Steroid receptor coactivator protein 3; SRC-3; Receptor-associated coactivator 3; RAC-3; RAC3; PCIP; NCoA-3; Class E basic helix-loop-helix protein 42; CBP-interacting protein; bHLHe42; Amplified in breast cancer-1 protein; Amplified in breast cancer 1 protein; AIB1 (SRC-3); AIB-1; AIB1; ACTR
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [7]
2 Biochemical Activity [8]
3 Biochemical Activity [4]
4 Reconstituted Complex [4]
5 Reconstituted Complex [9]
Interacting Protein Name Nuclear receptor coactivator 1 (NCOA1) Interacting Protein Interacting Protein Info
UniProt ID
NCOA1_HUMAN 
Synonyms F.SRC.1; KAT13A; RIP160; SRC1; bHLHe42; bHLHe74
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [4]
2 Reconstituted Complex [9]
Transcription regulators [+] 2 Transcription regulators +
Interacting Target Name CREB-binding protein (CREBBP) Clinical trial Target Interacting Protein Info
UniProt ID
CBP_HUMAN 
Synonyms CREBbinding protein; CBP
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [8]
3 Biochemical Activity [1]
4 Biochemical Activity [10]
5 Biochemical Activity [5]
6 Reconstituted Complex [1]
7 Yeast two hybrid [1]
Interacting Protein Name Nuclear receptor coactivator 2 (NCOA2) Interacting Protein Interacting Protein Info
UniProt ID
NCOA2_HUMAN 
Synonyms GRIP1; KAT13C; NCoA.2; SRC2; TIF2; bHLHe75
Evidence Score (E-score) 2 Experimental Evidences +
1 Biochemical Activity [4]
2 Reconstituted Complex [9]
References  Top
REF 1 A transcriptional switch mediated by cofactor methylation. Science. 2001 Dec 21;294(5551):2507-11.
REF 2 Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. J Mol Biol. 2008 Mar 28;377(3):668-78.
REF 3 Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell. 2017 Sep 7;67(5):733-743.e4.
REF 4 Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly. Mol Cell Biol. 2006 Nov;26(21):7846-57.
REF 5 Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination. Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3611-6.
REF 6 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 7 Selective phosphorylations of the SRC-3/AIB1 coactivator integrate genomic reponses to multiple cellular signaling pathways. Mol Cell. 2004 Sep 24;15(6):937-49.
REF 8 The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol. 2007 Jan;27(1):120-34.
REF 9 Dual role of the arginine methyltransferase CARM1 in the regulation of c-Fos target genes. FASEB J. 2008 Sep;22(9):3337-47.
REF 10 Control of CBP co-activating activity by arginine methylation. EMBO J. 2002 Oct 15;21(20):5457-66.

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