Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T12355 Target Info
Target Name G1/S-specific cyclin-D1 (CCND1)
Synonyms PRAD1 oncogene; PRAD1; Cyclin D1; BCL1; BCL-1 oncogene; BCL-1; B-cell lymphoma 1 protein
Target Type Clinical trial Target
Gene Name CCND1
UniProt ID
CCND1_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 2 Acyltransferases +
Interacting Target Name Histone acetyltransferase p300 (EP300) Clinical trial Target Interacting Protein Info
UniProt ID
EP300_HUMAN 
Synonyms Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Interacting Protein Name Transcription initiation factor TFIID subunit 1 (TAF1) Interacting Protein Interacting Protein Info
UniProt ID
TAF1_HUMAN 
Synonyms BA2R; CCG1; CCGS; DYT3; DYT3/TAF1; KAT4; N.TAF1; NSCL2; OF; P250; TAF(II)250; TAF2A; TAFII.250; TAFII250; XDP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
Carbon-nitrogen hydrolases [+] 2 Carbon-nitrogen hydrolases +
Interacting Target Name Histone deacetylase 3 (HDAC3) Clinical trial Target Interacting Protein Info
UniProt ID
HDAC3_HUMAN 
Synonyms SMAP45; RPD3-2; RPD32; HD3
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [7]
4 Co-localization [8]
Interacting Target Name Histone deacetylase 1 (HDAC1) Successful Target Interacting Protein Info
UniProt ID
HDAC1_HUMAN 
Synonyms RPD3L1; HD1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Co-localization [8]
Cell cycle related proteins [+] 1 Cell cycle related proteins +
Interacting Target Name Multiple tumor suppressor 1 (CDKN2A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN2A_HUMAN 
Synonyms Tumour suppressor gene p16; P16-INK4a; p16INK4A; P16-INK4; P16 gene; MTS-1; Cyclin-dependent kinase inhibitor 2A; Cyclin-dependent kinase 4 inhibitor A; CDK4I
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [9]
2 Co-fractionation [10]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Protein Name Retinoblastoma-associated protein (RB1) Interacting Protein Interacting Protein Info
UniProt ID
RB_HUMAN 
Synonyms OSRC; PPP1R130; RB; p105.Rb; pRb; pp110
Evidence Score (E-score) 15 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Biochemical Activity [12]
3 Biochemical Activity [13]
4 Biochemical Activity [14]
5 Biochemical Activity [15]
6 Biochemical Activity [16]
7 Biochemical Activity [11]
8 Biochemical Activity [17]
9 Biochemical Activity [18]
10 Biochemical Activity [19]
11 Biochemical Activity [20]
12 Biochemical Activity [21]
13 Biochemical Activity [22]
14 Reconstituted Complex [4]
15 Reconstituted Complex [23]
Kinases [+] 4 Kinases +
Interacting Target Name Cyclin-dependent kinase 4 (CDK4) Successful Target Interacting Protein Info
UniProt ID
CDK4_HUMAN 
Synonyms PSK-J3; Cell division protein kinase 4
Evidence Score (E-score) 20 Experimental Evidences +
1 Affinity Capture-MS [24]
2 Affinity Capture-MS [25]
3 Affinity Capture-Western [26]
4 Affinity Capture-Western [13]
5 Affinity Capture-Western [15]
6 Affinity Capture-Western [27]
7 Affinity Capture-Western [28]
8 Affinity Capture-Western [29]
9 Affinity Capture-Western [30]
10 Affinity Capture-Western [31]
11 Affinity Capture-Western [32]
12 Affinity Capture-Western [33]
13 Affinity Capture-Western [34]
14 Affinity Capture-Western [35]
15 Affinity Capture-Western [36]
16 Affinity Capture-Western [37]
17 Co-fractionation [38]
18 Co-fractionation [10]
19 Reconstituted Complex [39]
20 Reconstituted Complex [35]
Interacting Target Name Cyclin-dependent kinase 6 (CDK6) Successful Target Interacting Protein Info
UniProt ID
CDK6_HUMAN 
Synonyms Serine/threonine-protein kinase PLSTIRE; Serine/threonine protein kinase PLSTIRE; Cell division protein kinase 6; CDKN6
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [15]
2 Affinity Capture-Western [36]
3 Co-fractionation [10]
4 Reconstituted Complex [39]
Interacting Target Name Cyclin-dependent kinase 1 (CDK1) Clinical trial Target Interacting Protein Info
UniProt ID
CDK1_HUMAN 
Synonyms P34CDC2; P34 protein kinase; CDKN1; CDC28A; CDC2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [24]
2 Affinity Capture-MS [9]
3 Affinity Capture-Western [40]
Interacting Target Name Cyclin-dependent kinase 2 (CDK2) Clinical trial Target Interacting Protein Info
UniProt ID
CDK2_HUMAN 
Synonyms SIN3-associated protein; Sin3 associated polypeptide; P33 protein kinase; Cell division protein kinase 2; CDKN2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [24]
2 Affinity Capture-Western [15]
Nuclear hormone receptors [+] 2 Nuclear hormone receptors +
Interacting Target Name Estrogen receptor (ESR) Successful Target Interacting Protein Info
UniProt ID
ESR1_HUMAN 
Synonyms Oestrogen receptor alpha; Oestrogen receptor; Nuclear receptor subfamily 3 group A member 1; NR3A1; Estrogen receptor alpha; Estradiol receptor; ESR; ER-alpha; ERalpha; ER
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [41]
2 Reconstituted Complex [42]
3 Yeast two hybrid [42]
Interacting Target Name Androgen receptor (AR) Successful Target Interacting Protein Info
UniProt ID
ANDR_HUMAN 
Synonyms Testosterone receptor; Nuclear receptor subfamily 3 group C member 4; NR3C4; Dihydrotestosterone receptor; DHTR; Androgen receptor
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [43]
3 Reconstituted Complex [5]
Other proteins [+] 5 Other proteins +
Interacting Target Name Melanoma differentiation-associated protein 6 (CDKN1A) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1A_HUMAN 
Synonyms WAF1; SDI1; PIC1; P21(WAF1); P21; Melanoma differentiation associated protein 6; MDA-6; MDA6; Cyclin-dependent kinase inhibitor 1; CIP1; CDK-interacting protein 1; CAP20
Evidence Score (E-score) 13 Experimental Evidences +
1 Affinity Capture-MS [24]
2 Affinity Capture-Western [44]
3 Affinity Capture-Western [34]
4 Affinity Capture-Western [35]
5 Affinity Capture-Western [45]
6 Affinity Capture-Western [16]
7 Co-fractionation [10]
8 Reconstituted Complex [46]
9 Reconstituted Complex [47]
10 Reconstituted Complex [35]
11 Reconstituted Complex [39]
12 Yeast two hybrid [48]
13 Yeast two hybrid [49]
Interacting Target Name CDK inhibitor 1B p27Kip1 (CDKN1B) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1B_HUMAN 
Synonyms p27Kip1; KIP1; Cyclin-dependent kinase inhibitor p27; Cyclindependent kinase inhibitor p27; Cyclin-dependent kinase inhibitor 1B
Evidence Score (E-score) 10 Experimental Evidences +
1 Affinity Capture-MS [24]
2 Affinity Capture-MS [9]
3 Affinity Capture-Western [50]
4 Affinity Capture-Western [31]
5 Affinity Capture-Western [32]
6 Affinity Capture-Western [33]
7 Affinity Capture-Western [45]
8 Affinity Capture-Western [51]
9 Reconstituted Complex [52]
10 Yeast two hybrid [48]
Interacting Protein Name F-box only protein 4 (FBXO4) Interacting Protein Interacting Protein Info
UniProt ID
FBX4_HUMAN 
Synonyms FBX4
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [53]
2 Affinity Capture-Western [26]
3 Affinity Capture-Western [54]
4 Reconstituted Complex [53]
Interacting Target Name Proliferating cell nuclear antigen (PCNA) Clinical trial Target Interacting Protein Info
UniProt ID
PCNA_HUMAN 
Synonyms Cyclin
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [55]
2 Affinity Capture-Western [40]
3 Reconstituted Complex [56]
Interacting Target Name CDK inhibitor 1C p57Kip2 (CDKN1C) Literature-reported Target Interacting Protein Info
UniProt ID
CDN1C_HUMAN 
Synonyms P57KIP2; P57(KIP2); KIP2; Cyclin-dependent kinase inhibitor p57; Cyclin-dependent kinase inhibitor 1C
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [57]
2 Reconstituted Complex [58]
References  Top
REF 1 Cyclin D1 represses p300 transactivation through a cyclin-dependent kinase-independent mechanism. J Biol Chem. 2005 Aug 19;280(33):29728-42.
REF 2 Cyclin D1 represses the basic helix-loop-helix transcription factor, BETA2/NeuroD. J Biol Chem. 2002 Mar 15;277(11):8847-53.
REF 3 Cyclin D1 associates with the TBP-associated factor TAF(II)250 to regulate Sp1-mediated transcription. Oncogene. 1999 Jan 7;18(1):239-47.
REF 4 Cyclin D1 suppresses retinoblastoma protein-mediated inhibition of TAFII250 kinase activity. Oncogene. 2000 Nov 23;19(50):5703-11.
REF 5 A central domain of cyclin D1 mediates nuclear receptor corepressor activity. Oncogene. 2005 Jan 13;24(3):431-44.
REF 6 Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cells. Mol Cancer Ther. 2010 Jun;9(6):1596-608.
REF 7 Cyclin D1 Is a Ligand-independent Co-repressor for Thyroid Hormone Receptors. J Biol Chem. 2002 Aug 9;277(32):28733-41.
REF 8 Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. J Biol Chem. 2005 Apr 29;280(17):16934-41.
REF 9 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 10 CDK4 and CDK6 delay senescence by kinase-dependent and p16INK4a-independent mechanisms. Mol Cell Biol. 2007 Jun;27(12):4273-82.
REF 11 Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis. Mol Cell Biol. 2004 Nov;24(21):9527-41.
REF 12 Biologic and biochemical analyses of p16(INK4a) mutations from primary tumors. J Natl Cancer Inst. 1999 Sep 15;91(18):1569-74.
REF 13 Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/Tyr-15 phosphorylation after UV-induced DNA damage. J Biol Chem. 1996 May 31;271(22):13283-91.
REF 14 Cyclin-dependent kinase-2 (Cdk2) forms an inactive complex with cyclin D1 since Cdk2 associated with cyclin D1 is not phosphorylated by Cdk7-cyclin-H. Eur J Biochem. 1996 Apr 15;237(2):460-7.
REF 15 Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells. Oncogene. 1997 Mar 20;14(11):1329-40.
REF 16 p21WAF1/CIP1 mutants deficient in inhibiting cyclin-dependent kinases (CDKs) can promote assembly of active cyclin D/CDK4(6) complexes in human tumor cells. Cancer Res. 1998 Nov 15;58(22):5053-6.
REF 17 Inducible expression of cyclin D1 in T-47D human breast cancer cells is sufficient for Cdk2 activation and pRB hyperphosphorylation. J Cell Biochem. 1996 Mar 1;60(3):363-78.
REF 18 Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell. 1997 Feb;8(2):287-301.
REF 19 The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J. 1996 Dec 16;15(24):7060-9.
REF 20 Cyclin-dependent kinases phosphorylate p73 at threonine 86 in a cell cycle-dependent manner and negatively regulate p73. J Biol Chem. 2003 Jul 25;278(30):27421-31.
REF 21 Differential phosphorylation of the retinoblastoma protein by G1/S cyclin-dependent kinases. J Biol Chem. 1997 May 9;272(19):12738-46.
REF 22 Direct interaction of p21 cyclin-dependent kinase inhibitor with the retinoblastoma tumor suppressor protein. Biochem Biophys Res Commun. 1999 Sep 16;263(1):35-40.
REF 23 Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma protein. Oncogene. 2001 Sep 27;20(43):6152-63.
REF 24 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 25 Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library. J Proteome Res. 2013 Jul 5;12(7):3181-92.
REF 26 Fbxo4-mediated degradation of Fxr1 suppresses tumorigenesis in head and neck squamous cell carcinoma. Nat Commun. 2017 Nov 16;8(1):1534.
REF 27 Regulation of CDK4 activity by a novel CDK4-binding protein, p34(SEI-1). Genes Dev. 1999 Nov 15;13(22):3027-33.
REF 28 Calmodulin is essential for cyclin-dependent kinase 4 (Cdk4) activity and nuclear accumulation of cyclin D1-Cdk4 during G1. J Biol Chem. 1998 Dec 11;273(50):33279-86.
REF 29 BCR-ABL1-induced expression of HSPA8 promotes cell survival in chronic myeloid leukaemia. Br J Haematol. 2008 Aug;142(4):571-82.
REF 30 A critical role for FBXW8 and MAPK in cyclin D1 degradation and cancer cell proliferation. PLoS One. 2006 Dec 27;1:e128.
REF 31 Growth arrest by the cyclin-dependent kinase inhibitor p27Kip1 is abrogated by c-Myc. EMBO J. 1996 Dec 2;15(23):6595-604.
REF 32 VHL-mediated hypoxia regulation of cyclin D1 in renal carcinoma cells. Cancer Res. 2002 Jun 1;62(11):3014-9.
REF 33 Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation. Oncogene. 2009 Dec 10;28(49):4317-25.
REF 34 Nucleolar GTP-binding Protein-1 (NGP-1) Promotes G1 to S Phase Transition by Activating Cyclin-dependent Kinase Inhibitor p21 Cip1/Waf1. J Biol Chem. 2015 Aug 28;290(35):21536-52.
REF 35 Tyrosine phosphorylation of the p21 cyclin-dependent kinase inhibitor facilitates the development of proneural glioma. J Biol Chem. 2012 Nov 9;287(46):38523-30.
REF 36 Inhibition of cyclin E-cyclin-dependent kinase 2 complex formation and activity is associated with cell cycle arrest and withdrawal in oligodendrocyte progenitor cells. J Neurosci. 2001 Feb 15;21(4):1274-82.
REF 37 Schizophrenia susceptibility gene product dysbindin-1 regulates the homeostasis of cyclin D1. Biochim Biophys Acta. 2016 Aug;1862(8):1383-91.
REF 38 The cyclin D1-dependent kinase associates with the pre-replication complex and modulates RB.MCM7 binding. J Biol Chem. 2003 Mar 14;278(11):9754-60.
REF 39 Self-assembling protein microarrays. Science. 2004 Jul 2;305(5680):86-90.
REF 40 Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes. Mol Biol Cell. 1993 Sep;4(9):897-906.
REF 41 Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity. Cancer Res. 2005 Aug 1;65(15):6557-67.
REF 42 CDK-independent activation of estrogen receptor by cyclin D1. Cell. 1997 Feb 7;88(3):405-15.
REF 43 D-type cyclins complex with the androgen receptor and inhibit its transcriptional transactivation ability. Cancer Res. 1999 May 15;59(10):2297-301.
REF 44 Yin Yang-1 inhibits vascular smooth muscle cell growth and intimal thickening by repressing p21WAF1/Cip1 transcription and p21WAF1/Cip1-Cdk4-cyclin D1 assembly. Circ Res. 2007 Jul 20;101(2):146-55.
REF 45 Retinoic acid inhibits the proliferative response induced by CD40 activation and interleukin-4 in mantle cell lymphoma. Cancer Res. 2005 Jan 15;65(2):587-95.
REF 46 Analysis of wild-type and mutant p21WAF-1 gene activities. Mol Cell Biol. 1996 Apr;16(4):1786-93.
REF 47 Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol. 1996 Sep;16(9):4673-82.
REF 48 A proteome-scale map of the human interactome network. Cell. 2014 Nov 20;159(5):1212-1226.
REF 49 Toward an understanding of the protein interaction network of the human liver. Mol Syst Biol. 2011 Oct 11;7:536.
REF 50 Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases. Cell. 2007 Jan 26;128(2):269-80.
REF 51 Regulated expression of cofilin and the consequent regulation of p27(kip1) are essential for G(1) phase progression. Cell Cycle. 2009 Aug;8(15):2365-74.
REF 52 C-terminal phosphorylation controls the stability and function of p27kip1. EMBO J. 2006 Nov 1;25(21):5159-70.
REF 53 Phosphorylation-dependent ubiquitination of cyclin D1 by the SCF(FBX4-alphaB crystallin) complex. Mol Cell. 2006 Nov 3;24(3):355-66.
REF 54 The FBXO4 tumor suppressor functions as a barrier to BRAFV600E-dependent metastatic melanoma. Mol Cell Biol. 2013 Nov;33(22):4422-33.
REF 55 Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation. Genes Dev. 1993 Aug;7(8):1572-83.
REF 56 D-type cyclin-binding regions of proliferating cell nuclear antigen. J Biol Chem. 1994 Apr 15;269(15):11030-6.
REF 57 Dimerization of the amino terminal domain of p57Kip2 inhibits cyclin D1-cdk4 kinase activity. Oncogene. 2000 Feb 24;19(9):1147-52.
REF 58 Stabilization of MyoD by direct binding to p57(Kip2). J Biol Chem. 2000 Jun 23;275(25):18767-76.

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