Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T12290 Target Info
Target Name Guanine nucleotide-binding alpha-q (GNAQ)
Synonyms GNAQ; G alphaq; G alpha(q)
Target Type Literature-reported Target
Gene Name GNAQ
UniProt ID
GNAQ_HUMAN 
Target Interacting Proteins  Top
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Phospholipase C-beta-1 (PLCB1) Literature-reported Target Interacting Protein Info
UniProt ID
PLCB1_HUMAN 
Synonyms PLC-I; PLC-beta-1; PLC-154; Phospholipase C-I; Phospholipase C-beta1; Phosphoinositide phospholipase C-beta-1; Phosphoinositide phospholipase C; KIAA0581; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [2]
3 Fluorescence Resonance Energy Transfer [1]
4 Reconstituted Complex [1]
G-protein-coupled receptors [+] 1 G-protein-coupled receptors +
Interacting Target Name Thromboxane A2 receptor (TBXA2R) Successful Target Interacting Protein Info
UniProt ID
TA2R_HUMAN 
Synonyms TXA2-R; TXA2 receptor; Prostanoid TP receptor
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Co-crystal Structure [4]
3 Fluorescence Resonance Energy Transfer [5]
4 Reconstituted Complex [4]
Other proteins [+] 2 Other proteins +
Interacting Target Name Synembryn-A (RIC8A) Literature-reported Target Interacting Protein Info
UniProt ID
RIC8A_HUMAN 
Synonyms Protein Ric-8A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [7]
3 Yeast two hybrid [7]
Interacting Target Name Regulator of G-protein signaling 4 (RGS4) Literature-reported Target Interacting Protein Info
UniProt ID
RGS4_HUMAN 
Synonyms RGP4
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [8]
2 Reconstituted Complex [8]
References  Top
REF 1 Stable association between G alpha(q) and phospholipase C beta 1 in living cells. J Biol Chem. 2006 Aug 18;281(33):23999-4014.
REF 2 A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q. Nat Struct Biol. 2002 Jan;9(1):32-6.
REF 3 WDR36 acts as a scaffold protein tethering a G-protein-coupled receptor, Gq and phospholipase C in a signalling complex. J Cell Sci. 2011 Oct 1;124(Pt 19):3292-304.
REF 4 Structural and functional analysis of the C-terminus of Galphaq in complex with the human thromboxane A2 receptor provides evidence of constitutive activity. Biochemistry. 2010 Aug 3;49(30):6365-74.
REF 5 Real-time monitoring of receptor and G-protein interactions in living cells. Nat Methods. 2005 Mar;2(3):177-84.
REF 6 Ric-8A potentiates Gq-mediated signal transduction by acting downstream of G protein-coupled receptor in intact cells. Genes Cells. 2006 May;11(5):487-98.
REF 7 Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. J Biol Chem. 2003 Mar 7;278(10):8356-62.
REF 8 RGS16 inhibits signalling through the G alpha 13-Rho axis. Nat Cell Biol. 2003 Dec;5(12):1095-103.

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