Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T12108 Target Info
Target Name Cryptochrome circadian clock 1 (CRY1)
Synonyms PHLL1; Cryptochrome-1
Target Type Preclinical Target
Gene Name CRY1
UniProt ID
CRY1_HUMAN 
Target Interacting Proteins  Top
Cullins [+] 1 Cullins +
Interacting Protein Name Cullin-1 (CUL1) Interacting Protein Interacting Protein Info
UniProt ID
CUL1_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [3]
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Protein Name PP2A subunit A isoform PR65-beta (PPP2R1B) Interacting Protein Interacting Protein Info
UniProt ID
2AAB_HUMAN 
Synonyms PP2A.Abeta; PR65B
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [4]
Transcription regulators [+] 3 Transcription regulators +
Interacting Protein Name Period circadian protein homolog 2 (PER2) Interacting Protein Interacting Protein Info
UniProt ID
PER2_HUMAN 
Synonyms FASPS; FASPS1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [5]
3 Yeast two hybrid [4]
Interacting Protein Name Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) Interacting Protein Interacting Protein Info
UniProt ID
BMAL1_HUMAN 
Synonyms BMAL1; BMAL1c; JAP3; MOP3; PASD3; TIC; bHLHe5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Luminescence [4]
2 Affinity Capture-MS [1]
Interacting Protein Name Period circadian protein homolog 1 (PER1) Interacting Protein Interacting Protein Info
UniProt ID
PER1_HUMAN 
Synonyms PER; RIGUI; hPER
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Yeast two hybrid [4]
Other proteins [+] 2 Other proteins +
Interacting Protein Name F-box/LRR-repeat protein 3 (FBXL3) Interacting Protein Interacting Protein Info
UniProt ID
FBXL3_HUMAN 
Synonyms FBL3; FBL3A; FBXL3A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [1]
Interacting Protein Name S-phase kinase-associated protein 1 (SKP1) Interacting Protein Interacting Protein Info
UniProt ID
SKP1_HUMAN 
Synonyms EMC19; OCP.II; OCP2; SKP1A; TCEB1L; p19A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
References  Top
REF 1 DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Elife. 2015 Mar 10;4.
REF 2 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 3 SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science. 2007 May 11;316(5826):900-4.
REF 4 Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions. PLoS Genet. 2013 Mar;9(3):e1003398.
REF 5 Nuclear entry mechanism of rat PER2 (rPER2): role of rPER2 in nuclear localization of CRY protein. Mol Cell Biol. 2001 Oct;21(19):6651-9.

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