Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T10899 Target Info
Target Name Ubiquitin carboxyl-terminal hydrolase 37 (USP37)
Synonyms Ubiquitin-specific-processing protease 37; Ubiquitin thioesterase 37; KIAA1594; Deubiquitinating enzyme 37
Target Type Literature-reported Target
Gene Name USP37
Biochemical Class Peptidase
UniProt ID
UBP37_HUMAN 
Target Interacting Proteins  Top
Ubiquitin related proteins [+] 4 Ubiquitin related proteins +
Interacting Target Name Polyubiquitin-C (UBC) Patented-recorded Target Interacting Protein Info
UniProt ID
UBC_HUMAN 
Synonyms HMG20; ubiquitin C
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Biochemical Activity [1]
3 Protein-peptide [2]
4 Reconstituted Complex [1]
5 Reconstituted Complex [3]
Interacting Protein Name Anaphase-promoting complex subunit 5 (ANAPC5) Interacting Protein Interacting Protein Info
UniProt ID
APC5_HUMAN 
Synonyms APC5
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Proximity Label-MS [5]
Interacting Protein Name Anaphase-promoting complex subunit 7 (ANAPC7) Interacting Protein Interacting Protein Info
UniProt ID
APC7_HUMAN 
Synonyms APC7
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Proximity Label-MS [5]
Interacting Protein Name Cell division cycle protein 27 homolog (CDC27) Interacting Protein Interacting Protein Info
UniProt ID
CDC27_HUMAN 
Synonyms ANAPC3; APC3; CDC27Hs; D0S1430E; D17S978E; H.NUC; HNUC; NUC2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [4]
2 Proximity Label-MS [5]
Other proteins [+] 3 Other proteins +
Interacting Protein Name F-box/WD repeat-containing protein 1A (BTRC) Interacting Protein Interacting Protein Info
UniProt ID
FBW1A_HUMAN 
Synonyms BETA.TRCP; FBW1A; FBXW1; FBXW1A; FWD1; bTrCP; bTrCP1; betaTrCP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Proximity Label-MS [5]
Interacting Protein Name F-box/WD repeat-containing protein 11 (FBXW11) Interacting Protein Interacting Protein Info
UniProt ID
FBW1B_HUMAN 
Synonyms BTRC2; BTRCP2; FBW1B; FBXW1B; Fbw11; Hos
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Proximity Label-MS [5]
Interacting Protein Name S-phase kinase-associated protein 1 (SKP1) Interacting Protein Interacting Protein Info
UniProt ID
SKP1_HUMAN 
Synonyms EMC19; OCP.II; OCP2; SKP1A; TCEB1L; p19A
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Proximity Label-MS [5]
References  Top
REF 1 Ubiquitin-interacting motifs confer full catalytic activity, but not ubiquitin chain substrate specificity, to deubiquitinating enzyme USP37. J Biol Chem. 2014 Jan 24;289(4):2415-23.
REF 2 A strategy for modulation of enzymes in the ubiquitin system. Science. 2013 Feb 1;339(6119):590-5.
REF 3 Tandem UIMs confer Lys48 ubiquitin chain substrate preference to deubiquitinase USP25. Sci Rep. 2017 Mar 22;7:45037.
REF 4 Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry. Mol Cell. 2011 May 20;42(4):511-23.
REF 5 The Deubiquitinase USP37 Regulates Chromosome Cohesion and Mitotic Progression. Curr Biol. 2015 Aug 31;25(17):2290-9.
REF 6 Skp1-Cul1-F-box ubiquitin ligase (SCF(TrCP))-mediated destruction of the ubiquitin-specific protease USP37 during G2-phase promotes mitotic entry. J Biol Chem. 2012 Nov 9;287(46):39021-9.
REF 7 Defining the human deubiquitinating enzyme interaction landscape. Cell. 2009 Jul 23;138(2):389-403.

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