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| Target General Information |
Top |
| Target ID |
T09128 |
Target Info
|
| Target Name |
Caspase-2 (CASP2) |
| Synonyms |
Protease ICH1; Protease ICH-1; Neural precursor cell expressed developmentally downregulated protein 2; Neural precursor cell expressed developmentally down-regulated protein 2; NEDD2; NEDD-2; ICH1; Caspase2 subunit p12; CASP-2 |
| Target Type |
Patented-recorded Target |
| Gene Name |
CASP2 |
| Biochemical Class |
Peptidase |
| UniProt ID |
|
| Target Interacting Proteins |
Top |
| Adapter proteins |
[+] 1 Adapter proteins |
+ |
| Interacting Protein Name |
Death domain-containing protein CRADD (CRADD) |
Interacting Protein |
Interacting Protein Info
|
| UniProt ID |
|
| Synonyms |
MRT34; RAIDD |
| Evidence Score (E-score) |
3 Experimental Evidences |
+ |
| 1 |
Affinity Capture-MS |
[1] |
| 2 |
Affinity Capture-Western |
[2] |
| 3 |
Yeast two hybrid |
[3] |
| References |
Top |
| REF 1 |
Dimer-specific immunoprecipitation of active caspase-2 identifies TRAF proteins as novel activators. EMBO J. 2018 Jul 13;37(14). pii: e97072.
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| REF 2 |
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress. Science. 2004 May 7;304(5672):843-6.
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| REF 3 |
Identification of a caspase-2 isoform that behaves as an endogenous inhibitor of the caspase cascade. Cancer Res. 2000 Dec 15;60(24):7039-47.
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