Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T08813 Target Info
Target Name cAMP-dependent protein kinase A type I (PRKAR1A)
Synonyms cAMP-dependent protein kinase type I-alpha regulatory subunit; Tissue-specific extinguisher 1; TSE1; PRKAR1; PKR1
Target Type Literature-reported Target
Gene Name PRKAR1A
Biochemical Class Kinase
UniProt ID
KAP0_HUMAN 
Target Interacting Proteins  Top
Kinases [+] 1 Kinases +
Interacting Protein Name cAMP-dependent protein kinase catalytic subunit alpha (PRKACA) Interacting Protein Interacting Protein Info
UniProt ID
KAPCA_HUMAN 
Synonyms PKACA; PKA C-alpha; cAMP-dependent protein kinase catalytic subunit alpha
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Reconstituted Complex [2]
Transcription regulators [+] 1 Transcription regulators +
Interacting Protein Name Zinc finger BED domain-containing protein 1 (ZBED1) Interacting Protein Interacting Protein Info
UniProt ID
ZBED1_HUMAN 
Synonyms ALTE; DREF; TRAMP; hDREF
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Yeast two hybrid [4]
Other proteins [+] 2 Other proteins +
Interacting Protein Name cAMP-dependent protein kinase type I-beta regulatory subunit (PRKAR1B) Interacting Protein Interacting Protein Info
UniProt ID
KAP1_HUMAN 
Synonyms PRKAR1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [5]
3 Reconstituted Complex [5]
4 Yeast two hybrid [6]
Interacting Protein Name Protein kinase A-anchoring protein 10 (AKAP10) Interacting Protein Interacting Protein Info
UniProt ID
AKA10_HUMAN 
Synonyms AKAP.10; D.AKAP.2; D.AKAP2; PRKA10
Evidence Score (E-score) 2 Experimental Evidences +
1 Reconstituted Complex [7]
2 Yeast two hybrid [7]
References  Top
REF 1 Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. Nat Methods. 2013 Apr;10(4):307-14.
REF 2 Protein kinase A phosphorylates and regulates dimerization of 14-3-3 epsilon. FEBS Lett. 2006 Jan 9;580(1):305-10.
REF 3 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 4 A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 2011 Sep 6;4(189):rs8.
REF 5 Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes. J Biol Chem. 1993 Oct 5;268(28):21276-83.
REF 6 A kinase anchoring protein (AKAP) interaction and dimerization of the RIalpha and RIbeta regulatory subunits of protein kinase a in vivo by the yeast two hybrid system. J Mol Biol. 2003 Mar 28;327(3):609-18.
REF 7 D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11184-9.

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