Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T08123 Target Info
Target Name Leucine-rich repeat kinase 2 (LRRK2)
Synonyms PARK8; Leucine-rich repeat serine/threonine-protein kinase 2; Dardarin
Target Type Clinical trial Target
Gene Name LRRK2
Biochemical Class Kinase
UniProt ID
LRRK2_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 2 Acid anhydride hydrolases +
Interacting Protein Name Ras-related protein Rab-5B (RAB5B) Interacting Protein Interacting Protein Info
UniProt ID
RAB5B_HUMAN 
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Yeast two hybrid [1]
Interacting Protein Name Cell division control protein 42 homolog (CDC42) Interacting Protein Interacting Protein Info
UniProt ID
CDC42_HUMAN 
Synonyms CDC42Hs; G25K
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Biochemical Activity [4]
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name E3 ubiquitin-protein ligase CHIP (STUB1) Interacting Protein Interacting Protein Info
UniProt ID
CHIP_HUMAN 
Synonyms CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [5]
2 Affinity Capture-Western [6]
3 Affinity Capture-Western [7]
4 Reconstituted Complex [7]
5 Reconstituted Complex [8]
6 Reconstituted Complex [9]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name 14-3-3 protein zeta/delta (YWHAZ) Interacting Protein Interacting Protein Info
UniProt ID
1433Z_HUMAN 
Synonyms 14.3.3.zeta; HEL.S.3; HEL4; KCIP.1; YWHAD
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Reconstituted Complex [9]
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Target Name Hsp90 co-chaperone Cdc37 (CDC37) Literature-reported Target Interacting Protein Info
UniProt ID
CDC37_HUMAN 
Synonyms p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; Hsp90 chaperone protein kinase-targeting subunit; CDC37A
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Affinity Capture-MS [2]
3 Affinity Capture-Western [11]
4 Affinity Capture-Western [12]
5 Affinity Capture-Western [13]
Ester hydrolases [+] 2 Ester hydrolases +
Interacting Protein Name Protein argonaute-1 (AGO1) Interacting Protein Interacting Protein Info
UniProt ID
AGO1_HUMAN 
Synonyms EIF2C; EIF2C1; GERP95; Q99
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-Western [15]
Interacting Protein Name Protein argonaute-2 (AGO2) Interacting Protein Interacting Protein Info
UniProt ID
AGO2_HUMAN 
Synonyms EIF2C2; Q10
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-Western [15]
Heat shock proteins [+] 2 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 9 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Affinity Capture-MS [14]
3 Affinity Capture-MS [2]
4 Affinity Capture-MS [16]
5 Affinity Capture-Western [6]
6 Affinity Capture-Western [11]
7 Affinity Capture-Western [12]
8 Affinity Capture-Western [13]
9 Biochemical Activity [17]
Interacting Target Name Lipopolysaccharide-associated protein 1 (HSPA8) Literature-reported Target Interacting Protein Info
UniProt ID
HSP7C_HUMAN 
Synonyms LPS-associated protein 1; LAP-1; HSPA10; HSP73; HSC70; Heat shock protein 73; Heat shock cognate 71 kDa protein; Heat shock 70 kDa protein 8
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [14]
2 Affinity Capture-MS [16]
3 Affinity Capture-Western [11]
4 Affinity Capture-Western [7]
Kinases [+] 4 Kinases +
Interacting Target Name ERK activator kinase 7 (MAP2K7) Literature-reported Target Interacting Protein Info
UniProt ID
MP2K7_HUMAN 
Synonyms Stress-activated protein kinase kinase 4; SKK4; SAPKK-4; SAPKK4; SAPK kinase 4; PRKMK7; MKK7; Mitogen-activated protein kinase kinase 7; MEK7; MEK 7; MAPKK 7; MAPK/ERK kinase7; MAPK/ERK kinase 7; MAP kinase kinase 7; JNKK2; JNKK 2; JNK-activating kinase 2; JNK kinase 2; JNK activating kinase 2; Dual specificity mitogen-activated protein kinase kinase 7; C-Jun N-terminal kinase kinase 2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Biochemical Activity [19]
3 Biochemical Activity [18]
Interacting Protein Name Cyclin-G-associated kinase (GAK) Interacting Protein Interacting Protein Info
UniProt ID
GAK_HUMAN 
Synonyms DNAJ26; DNAJC26
Evidence Score (E-score) 3 Experimental Evidences +
1 Co-localization [9]
2 Reconstituted Complex [8]
3 Reconstituted Complex [9]
Interacting Protein Name Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) Interacting Protein Interacting Protein Info
UniProt ID
MP2K3_HUMAN 
Synonyms MAPKK3; MEK3; MKK3; PRKMK3; SAPKK.2; SAPKK2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [20]
2 Biochemical Activity [19]
3 Biochemical Activity [18]
Interacting Protein Name Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) Interacting Protein Interacting Protein Info
UniProt ID
MP2K6_HUMAN 
Synonyms MAPKK6; MEK6; MKK6; PRKMK6; SAPKK.3; SAPKK3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [18]
2 Biochemical Activity [19]
3 Biochemical Activity [18]
Proteins 14-3-3 [+] 2 Proteins 14-3-3 +
Interacting Protein Name 14-3-3 protein theta (YWHAQ) Interacting Protein Interacting Protein Info
UniProt ID
1433T_HUMAN 
Synonyms 14.3.3; 1C5; HS1
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Affinity Capture-Western [9]
3 Affinity Capture-Western [12]
Interacting Protein Name 14-3-3 protein beta/alpha (YWHAB) Interacting Protein Interacting Protein Info
UniProt ID
1433B_HUMAN 
Synonyms GW128; HEL.S.1; HS1; KCIP.1; YWHAA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [10]
2 Reconstituted Complex [9]
Other proteins [+] 4 Other proteins +
Interacting Protein Name ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) Interacting Protein Interacting Protein Info
UniProt ID
ARFG1_HUMAN 
Synonyms ARF1GAP; HRIHFB2281
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [21]
2 Affinity Capture-Western [22]
3 Biochemical Activity [21]
4 Biochemical Activity [22]
5 Reconstituted Complex [8]
Interacting Protein Name BAG family molecular chaperone regulator 5 (BAG5) Interacting Protein Interacting Protein Info
UniProt ID
BAG5_HUMAN 
Synonyms BAG.5
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Reconstituted Complex [9]
3 Yeast two hybrid [23]
Interacting Protein Name Tubulin alpha-1A chain (TUBA1A) Interacting Protein Interacting Protein Info
UniProt ID
TBA1A_HUMAN 
Synonyms B.ALPHA.1; LIS3; TUBA3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [24]
2 Affinity Capture-Western [25]
3 Biochemical Activity [24]
Interacting Protein Name Myosin regulatory light polypeptide 9 (MYL9) Interacting Protein Interacting Protein Info
UniProt ID
MYL9_HUMAN 
Synonyms LC20; MLC.2C; MLC2; MRLC1; MYRL2
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [26]
2 Reconstituted Complex [9]
References  Top
REF 1 LRRK2 regulates synaptic vesicle endocytosis. Exp Cell Res. 2008 Jun 10;314(10):2055-65.
REF 2 The Parkinson's Disease-Associated Protein Kinase LRRK2 Modulates Notch Signaling through the Endosomal Pathway. PLoS Genet. 2015 Sep 10;11(9):e1005503.
REF 3 Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2). J Biol Chem. 2011 May 6;286(18):16140-9.
REF 4 ARHGEF7 (Beta-PIX) acts as guanine nucleotide exchange factor for leucine-rich repeat kinase 2. PLoS One. 2010 Oct 29;5(10):e13762.
REF 5 CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2897-902.
REF 6 Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP. PLoS One. 2009 Jun 17;4(6):e5949.
REF 7 The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2. Biochem J. 2017 Apr 24;474(9):1547-1558.
REF 8 Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. Proteomics. 2018 May;18(10):e1700444.
REF 9 Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2626-31.
REF 10 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J. 2010 Sep 15;430(3):393-404.
REF 11 The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2. J Neurosci. 2008 Mar 26;28(13):3384-91.
REF 12 The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation. Biochem J. 2012 Aug 15;446(1):99-111.
REF 13 The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. Hum Mol Genet. 2006 Jan 15;15(2):223-32.
REF 14 Identification of potential protein interactors of Lrrk2. Parkinsonism Relat Disord. 2007 Oct;13(7):382-5.
REF 15 Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression. Nature. 2010 Jul 29;466(7306):637-41.
REF 16 Dependence of leucine-rich repeat kinase 2 (LRRK2) kinase activity on dimerization. J Biol Chem. 2009 Dec 25;284(52):36346-56.
REF 17 Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity. PLoS One. 2010 Oct 7;5(10):e13191.
REF 18 MKK6 binds and regulates expression of Parkinson's disease-related protein LRRK2. J Neurochem. 2010 Mar;112(6):1593-604.
REF 19 The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7, in vitro. J Neurochem. 2009 May;109(4):959-68.
REF 20 LRRK2 and the stress response: interaction with MKKs and JNK-interacting proteins. Neurodegener Dis. 2010;7(1-3):68-75.
REF 21 ArfGAP1 is a GTPase activating protein for LRRK2: reciprocal regulation of ArfGAP1 by LRRK2. J Neurosci. 2012 Mar 14;32(11):3877-86.
REF 22 GTPase activity and neuronal toxicity of Parkinson's disease-associated LRRK2 is regulated by ArfGAP1. PLoS Genet. 2012;8(2):e1002526.
REF 23 Screening of LRRK2 interactants by yeast 2-hybrid analysis. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2008 Oct;33(10):883-91.
REF 24 LRRK2 phosphorylates tubulin-associated tau but not the free molecule: LRRK2-mediated regulation of the tau-tubulin association and neurite outgrowth. PLoS One. 2012;7(1):e30834.
REF 25 LRRK2 kinase regulates synaptic morphology through distinct substrates at the presynaptic and postsynaptic compartments of the Drosophila neuromuscular junction. J Neurosci. 2010 Dec 15;30(50):16959-69.
REF 26 A QUICK screen for Lrrk2 interaction partners--leucine-rich repeat kinase 2 is involved in actin cytoskeleton dynamics. Mol Cell Proteomics. 2011 Jan;10(1):M110.001172.

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