Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T04386 | Target Info | |||
| Target Name | Annexin A2 (ANXA2) | ||||
| Synonyms | p36; Protein I; Placental anticoagulant protein IV; PAP-IV; Lipocortin II; LPC2D; Chromobindin-8; Calpactin-1 heavy chain; Calpactin I heavy chain; CAL1H; Annexin-2; Annexin II; ANX2L4; ANX2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | ANXA2 | ||||
| Biochemical Class | Annexin protein | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Adapter proteins | [+] 1 Adapter proteins | + | |||
| Interacting Protein Name | Growth factor receptor-bound protein 2 (GRB2) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | SH2/SH3 adapter GRB2; Protein Ash; Growth factor receptor-bound protein 2; ASH; Adapter protein GRB2 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| Auxiliary transporters | [+] 1 Auxiliary transporters | + | |||
| Interacting Protein Name | Protein S100-A10 (S100A10) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | 42C; ANX2L; ANX2LG; CAL1L; CLP11; Ca[1]; GP11; P11; p10 | ||||
| Evidence Score (E-score) | 4 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [3] | |||
| 2 | Affinity Capture-MS | [4] | |||
| 3 | Affinity Capture-Western | [5] | |||
| 4 | Reconstituted Complex | [6] | |||
| Other proteins | [+] 2 Other proteins | + | |||
| Interacting Target Name | Cytosolic phospholipase A2 (GIVA cPLA2) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | PLA2G4; Phospholipase A2 group IVA; CPLA2 | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [7] | |||
| 2 | Reconstituted Complex | [6] | |||
| Interacting Target Name | Proliferating cell nuclear antigen (PCNA) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Cyclin | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-MS | [8] | |||
| 2 | Affinity Capture-Western | [8] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Charting the molecular network of the drug target Bcr-Abl. Proc Natl Acad Sci U S A. 2009 May 5;106(18):7414-9. | ||||
| REF 2 | A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells. J Biol Chem. 1994 Mar 25;269(12):9019-23. | ||||
| REF 3 | Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509. | ||||
| REF 4 | The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell. 2015 Jul 16;162(2):425-440. | ||||
| REF 5 | Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11. J Biol Chem. 2008 Jul 11;283(28):19192-200. | ||||
| REF 6 | Mechanism of regulation of group IVA phospholipase A2 activity by Ser727 phosphorylation. J Biol Chem. 2008 Feb 15;283(7):3960-71. | ||||
| REF 7 | Cytosolic phospholipase A2-p11 interaction controls arachidonic acid release as a function of epithelial cell confluence. Biochem J. 2004 Mar 1;378(Pt 2):307-15. | ||||
| REF 8 | A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5 complex as a novel PCNA-binding protein. J Biol Chem. 2002 Oct 25;277(43):40362-7. | ||||
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