Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T04123 Target Info
Target Name Serine/threonine-protein phosphatase 5 (PPP5C)
Synonyms Protein phosphatase T; PPT protein; PPP5; PP5; PP-T
Target Type Patented-recorded Target
Gene Name PPP5C
Biochemical Class Phosphoric monoester hydrolase
UniProt ID
PPP5_HUMAN 
Target Interacting Proteins  Top
Cell division cycle proteins [+] 1 Cell division cycle proteins +
Interacting Target Name Hsp90 co-chaperone Cdc37 (CDC37) Literature-reported Target Interacting Protein Info
UniProt ID
CDC37_HUMAN 
Synonyms p50Cdc37; Hsp90 co-chaperone Cdc37, N-terminally processed; Hsp90 chaperone protein kinase-targeting subunit; CDC37A
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [1]
4 Affinity Capture-MS [3]
5 Affinity Capture-Western [2]
6 Biochemical Activity [4]
Heat shock proteins [+] 2 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 12 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [5]
3 Affinity Capture-MS [6]
4 Affinity Capture-MS [1]
5 Affinity Capture-MS [7]
6 Affinity Capture-MS [3]
7 Affinity Capture-MS [2]
8 Affinity Capture-Western [2]
9 Protein-peptide [8]
10 Proximity Label-MS [3]
11 Reconstituted Complex [9]
12 Reconstituted Complex [10]
Interacting Target Name Heat shock protein 90 beta (HSP90B) Clinical trial Target Interacting Protein Info
UniProt ID
HS90B_HUMAN 
Synonyms HSP84; HSP 84; Heat shock 84 kDa
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [2]
3 Affinity Capture-MS [6]
4 Affinity Capture-MS [1]
5 Affinity Capture-MS [7]
6 Affinity Capture-MS [3]
7 Proximity Label-MS [3]
Isomerases [+] 1 Isomerases +
Interacting Protein Name Prostaglandin E synthase 3 (PTGES3) Interacting Protein Interacting Protein Info
UniProt ID
TEBP_HUMAN 
Synonyms P23; TEBP; cPGES
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Luminescence [1]
2 Affinity Capture-MS [3]
3 Affinity Capture-MS [1]
Other proteins [+] 1 Other proteins +
Interacting Protein Name Stress-induced-phosphoprotein 1 (STIP1) Interacting Protein Interacting Protein Info
UniProt ID
STIP1_HUMAN 
Synonyms HEL.S.94n; HOP; IEF.SSP.3521; P60; STI1; STI1L
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [2]
2 Affinity Capture-MS [3]
3 Affinity Capture-Western [2]
4 Affinity Capture-Western [3]
References  Top
REF 1 A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. Cell. 2014 Jul 17;158(2):434-448.
REF 2 Label-free quantitative proteomics and SAINT analysis enable interactome mapping for the human Ser/Thr protein phosphatase 5. Proteomics. 2011 Apr;11(8):1508-16.
REF 3 Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. Cell Syst. 2017 Apr 26;4(4):430-444.e5.
REF 4 Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer. Cell Rep. 2017 Nov 14;21(7):1883-1895.
REF 5 Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole. Biochem J. 2005 Jan 1;385(Pt 1):45-56.
REF 6 A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell. 2015 Oct 22;163(3):712-23.
REF 7 Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. Cell Rep. 2016 Nov 22;17(9):2488-2501.
REF 8 Conformational diversity in the TPR domain-mediated interaction of protein phosphatase 5 with Hsp90. Structure. 2006 Mar;14(3):415-26.
REF 9 Designed hybrid TPR peptide targeting Hsp90 as a novel anticancer agent. J Transl Med. 2011 Jan 14;9:8.
REF 10 A truncated form of p23 down-regulates telomerase activity via disruption of Hsp90 function. J Biol Chem. 2009 Nov 6;284(45):30871-80.

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