Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T03772 Target Info
Target Name Herpesvirus entry mediator (CD270)
Synonyms UNQ329/PRO509; Tumor necrosis factor receptor-like 2; Tumor necrosis factor receptor superfamily member 14; TR2; HveA; Herpesvirus entry mediator A; Herpes virus entry mediator A; HVEM
Target Type Literature-reported Target
Gene Name TNFRSF14
Biochemical Class Cytokine receptor
UniProt ID
TNR14_HUMAN 
Target Interacting Proteins  Top
Acyltransferases [+] 1 Acyltransferases +
Interacting Protein Name TNF receptor-associated factor 2 (TRAF2) Interacting Protein Interacting Protein Info
UniProt ID
TRAF2_HUMAN 
Synonyms MGC:45012; TRAP; TRAP3
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Yeast two hybrid [1]
Adapter proteins [+] 1 Adapter proteins +
Interacting Protein Name TNF receptor-associated factor 5 (TRAF5) Interacting Protein Interacting Protein Info
UniProt ID
TRAF5_HUMAN 
Synonyms MGC:39780; RNF84
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
3 Yeast two hybrid [1]
Other proteins [+] 1 Other proteins +
Interacting Target Name Herpes virus entry mediator ligand (CD258) Clinical trial Target Interacting Protein Info
UniProt ID
TNF14_HUMAN 
Synonyms UNQ391/PRO726; Tumor necrosis factor ligand superfamily member 14, soluble form; Tumor necrosis factor ligand superfamily member 14; LIGHT; HVEM-L; HVEML; Herpesvirus entry mediator ligand
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [3]
2 Reconstituted Complex [4]
References  Top
REF 1 ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. J Biol Chem. 1997 May 23;272(21):13471-4.
REF 2 Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. J Biol Chem. 1997 May 30;272(22):14029-32.
REF 3 A newly identified member of tumor necrosis factor receptor superfamily (TR6) suppresses LIGHT-mediated apoptosis. J Biol Chem. 1999 May 14;274(20):13733-6.
REF 4 Modulation of T-cell responses to alloantigens by TR6/DcR3. J Clin Invest. 2001 Jun;107(11):1459-68.

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