Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T03346 Target Info
Target Name Interleukin 4 receptor alpha (IL4R)
Synonyms Interleukin-4 receptor subunit alpha; IL4RA; IL-4RA; IL-4R-alpha; IL-4R subunit alpha; IL-4 receptor subunit alpha; CD124 antigen; CD124; 582J2.1
Target Type Successful Target
Gene Name IL4R
Biochemical Class Cytokine receptor
UniProt ID
IL4RA_HUMAN 
Target Interacting Proteins  Top
Ester hydrolases [+] 1 Ester hydrolases +
Interacting Target Name Protein-tyrosine phosphatase SHP-1 (PTPN6) Patented-recorded Target Interacting Protein Info
UniProt ID
PTN6_HUMAN 
Synonyms Tyrosine-protein phosphatase non-receptor type 6; SH-PTP1; PTP-1C; PTP1C; Protein-tyrosine phosphatase 1C; Hematopoietic cell protein-tyrosine phosphatase; HCP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Reconstituted Complex [2]
Kinases [+] 1 Kinases +
Interacting Target Name Janus kinase 1 (JAK-1) Successful Target Interacting Protein Info
UniProt ID
JAK1_HUMAN 
Synonyms Tyrosine-protein kinase JAK1; JAK1B; JAK1A
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [3]
2 Affinity Capture-Western [4]
3 Reconstituted Complex [5]
Other proteins [+] 1 Other proteins +
Interacting Protein Name SHC-transforming protein 1 (SHC1) Interacting Protein Interacting Protein Info
UniProt ID
SHC1_HUMAN 
Synonyms SHC; SHCA
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-Western [6]
2 Reconstituted Complex [2]
References  Top
REF 1 The TORC1-activated Proteins, p70S6K and GRB10, Regulate IL-4 Signaling and M2 Macrophage Polarization by Modulating Phosphorylation of Insulin Rec... J Biol Chem. 2016 Nov 25;291(48):24922-24930.
REF 2 Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation. J Immunol. 2001 Dec 1;167(11):6382-7.
REF 3 Architecture of the human interactome defines protein communities and disease networks. Nature. 2017 May 25;545(7655):505-509.
REF 4 Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13003-8.
REF 5 Two distinct domains within the N-terminal region of Janus kinase 1 interact with cytokine receptors. J Immunol. 2002 Aug 1;169(3):1302-8.
REF 6 Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line. Biochem Biophys Res Commun. 2000 Feb 5;268(1):54-9.

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