Target Interacting Protein Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02723 | Target Info | |||
| Target Name | Interferon regulatory factor 1 (IRF1) | ||||
| Synonyms | IRF-1 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | IRF1 | ||||
| UniProt ID | |||||
| Target Interacting Proteins | Top | ||||
|---|---|---|---|---|---|
| Acyltransferases | [+] 3 Acyltransferases | + | |||
| Interacting Target Name | Histone acetyltransferase p300 (EP300) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Protein propionyltransferase p300; p300 HAT; P300; Histone crotonyltransferase p300; Histone butyryltransferase p300; E1A-associated protein p300; E1Aassociated protein p300 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [1] | |||
| 2 | Affinity Capture-Western | [2] | |||
| 3 | Reconstituted Complex | [3] | |||
| Interacting Protein Name | E3 ubiquitin-protein ligase CHIP (STUB1) | Interacting Protein | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | CHIP; HSPABP2; NY.CO.7; SCAR16; SDCCAG7; UBOX1 | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [4] | |||
| 2 | Affinity Capture-Western | [5] | |||
| 3 | Reconstituted Complex | [4] | |||
| Interacting Target Name | Histone acetyltransferase KAT2B (KAT2B) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | Spermidine acetyltransferase KAT2B; PCAF; P300/CBP-associated factor; P/CAF; Lysine acetyltransferase 2B; Histone acetyltransferase PCAF; Histone acetylase PCAF | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [2] | |||
| 2 | Reconstituted Complex | [6] | |||
| Transcription regulators | [+] 1 Transcription regulators | + | |||
| Interacting Target Name | Interferon consensus sequence binding protein (IRF8) | Literature-reported Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | IRF-8; Interferon regulatory factor 8; Interferon consensus sequence-binding protein; ICSBP1; ICSBP; H-ICSBP | ||||
| Evidence Score (E-score) | 2 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [7] | |||
| 2 | Yeast two hybrid | [8] | |||
| Ubiquitin related proteins | [+] 1 Ubiquitin related proteins | + | |||
| Interacting Target Name | Ubiquitin-protein ligase E3 Mdm2 (MDM2) | Clinical trial Target | Interacting Protein Info | ||
| UniProt ID | |||||
| Synonyms | RING-type E3 ubiquitin transferase Mdm2; P53-binding protein Mdm2; Oncoprotein Mdm2; MDM2 protein; Hdm2; E3 ubiquitin-protein ligase Mdm2; Double minute 2 protein | ||||
| Evidence Score (E-score) | 3 Experimental Evidences | + | |||
| 1 | Affinity Capture-Western | [9] | |||
| 2 | Affinity Capture-Western | [10] | |||
| 3 | Reconstituted Complex | [10] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Regulation of inducible nitric oxide synthase expression by p300 and p50 acetylation. J Immunol. 2003 Dec 15;171(12):6581-8. | ||||
| REF 2 | p300, but not PCAF, collaborates with IRF-1 in stimulating TRIM22 expression independently of its histone acetyltransferase activity. Eur J Immunol. 2013 Aug;43(8):2174-84. | ||||
| REF 3 | Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300. J Virol. 1999 Sep;73(9):7334-42. | ||||
| REF 4 | Docking-dependent ubiquitination of the interferon regulatory factor-1 tumor suppressor protein by the ubiquitin ligase CHIP. J Biol Chem. 2011 Jan 7;286(1):607-19. | ||||
| REF 5 | Inhibition of histone deacetylase activity suppresses IFN- induction of tripartite motif 22 via CHIP-mediated proteasomal degradation of IRF-1. J Immunol. 2013 Jul 1;191(1):464-71. | ||||
| REF 6 | The histone acetylase PCAF is a phorbol-ester-inducible coactivator of the IRF family that confers enhanced interferon responsiveness. Mol Cell Biol. 1999 Mar;19(3):1810-20. | ||||
| REF 7 | Functional domain analysis of interferon consensus sequence binding protein (ICSBP) and its association with interferon regulatory factors. J Biol Chem. 1995 Jun 2;270(22):13063-9. | ||||
| REF 8 | Functional domains of interferon regulatory factor I (IRF-1). Biochem J. 1998 Oct 1;335 ( Pt 1):147-57. | ||||
| REF 9 | HIV-1 Tat Recruits HDM2 E3 Ligase To Target IRF-1 for Ubiquitination and Proteasomal Degradation. MBio. 2016 Oct 18;7(5). pii: e01528-16. | ||||
| REF 10 | DNA-binding regulates site-specific ubiquitination of IRF-1. Biochem J. 2013 Feb 1;449(3):707-17. | ||||
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