Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T02703 Target Info
Target Name Nitric-oxide synthase inducible (NOS2)
Synonyms iNOS; Peptidyl-cysteine S-nitrosylase NOS2; Nitric oxide synthase, inducible; NOS2A; NOS type II; Inducible NOS; Inducible NO synthase; Hepatocyte NOS; HEP-NOS
Target Type Clinical trial Target
Gene Name NOS2
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
NOS2_HUMAN 
Target Interacting Proteins  Top
Cullins [+] 1 Cullins +
Interacting Protein Name Cullin-5 (CUL5) Interacting Protein Interacting Protein Info
UniProt ID
CUL5_HUMAN 
Synonyms VACM.1; VACM1
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
Heat shock proteins [+] 1 Heat shock proteins +
Interacting Target Name Heat shock protein 90 alpha (HSP90A) Successful Target Interacting Protein Info
UniProt ID
HS90A_HUMAN 
Synonyms Renal carcinoma antigen NY-REN-38; LPS-associated protein 2; Lipopolysaccharide-associated protein 2; LAP-2; HSPCA; HSPC1; HSP90A; HSP86; HSP 86; Heat shock protein HSP 90-alpha; Heat shock 86 kDa
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [3]
Peptidases [+] 1 Peptidases +
Interacting Target Name Ubiquitin C-terminal hydrolase UCH37 (UCHL5) Patented-recorded Target Interacting Protein Info
UniProt ID
UCHL5_HUMAN 
Synonyms UCH-L5; UCH37; Ubiquitin thioesterase L5; Ubiquitin carboxyl-terminal hydrolase isozyme L5; CGI-70; AD-019
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [4]
Other proteins [+] 2 Other proteins +
Interacting Protein Name SPRY domain-containing SOCS box protein 1 (SPSB1) Interacting Protein Interacting Protein Info
UniProt ID
SPSB1_HUMAN 
Synonyms SSB.1; SSB1
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [5]
4 Co-localization [2]
Interacting Protein Name SPRY domain-containing SOCS box protein 2 (SPSB2) Interacting Protein Interacting Protein Info
UniProt ID
SPSB2_HUMAN 
Synonyms GRCC9; SSB2
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [5]
References  Top
REF 1 Proteomic analysis of the NOS2 interactome in human airway epithelial cells. Nitric Oxide. 2013 Nov 1;34:37-46.
REF 2 Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins. J Biol Chem. 2011 Mar 18;286(11):9009-19.
REF 3 Heat shock protein 90 as an endogenous protein enhancer of inducible nitric-oxide synthase. J Biol Chem. 2003 Sep 19;278(38):36953-8.
REF 4 Regulation of NF-kappaB activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13). Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13854-9.
REF 5 The ECS(SPSB) E3 ubiquitin ligase is the master regulator of the lifetime of inducible nitric-oxide synthase. Biochem Biophys Res Commun. 2011 May 27;409(1):46-51.

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