Target Interacting Protein Information

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Target General Information
Target Interacting Proteins
References
Target General Information  Top
Target ID T01441 Target Info
Target Name Synovial apoptosis inhibitor 1 (SYVN1)
Synonyms RING-type E3 ubiquitin transferase synoviolin; KIAA1810; HRD1; E3 ubiquitinprotein ligase synoviolin; E3 ubiquitin-protein ligase synoviolin
Target Type Literature-reported Target
Gene Name SYVN1
Biochemical Class Acyltransferase
UniProt ID
SYVN1_HUMAN 
Target Interacting Proteins  Top
Acid anhydride hydrolases [+] 1 Acid anhydride hydrolases +
Interacting Target Name Valosin-containing protein p97 (VCP) Clinical trial Target Interacting Protein Info
UniProt ID
TERA_HUMAN 
Synonyms Valosin-containing protein; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit
Evidence Score (E-score) 8 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [3]
4 Affinity Capture-Western [4]
5 Co-fractionation [5]
6 Reconstituted Complex [1]
7 Reconstituted Complex [2]
8 Reconstituted Complex [6]
Auxiliary transporters [+] 1 Auxiliary transporters +
Interacting Protein Name Protein OS-9 (OS9) Interacting Protein Interacting Protein Info
UniProt ID
OS9_HUMAN 
Synonyms ERLEC2; OS.9
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [3]
3 Affinity Capture-Western [8]
G-protein-coupled receptors [+] 1 G-protein-coupled receptors +
Interacting Protein Name Prosaposin receptor GPR37 (GPR37) Interacting Protein Interacting Protein Info
UniProt ID
GPR37_HUMAN 
Synonyms EDNRBL; PAELR; hET(B)R.LP
Evidence Score (E-score) 4 Experimental Evidences +
1 Affinity Capture-Western [9]
2 Biochemical Activity [9]
3 Biochemical Activity [10]
4 Reconstituted Complex [9]
Holins [+] 1 Holins +
Interacting Protein Name Protein FAM8A1 (FAM8A1) Interacting Protein Interacting Protein Info
UniProt ID
FA8A1_HUMAN 
Synonyms AHCP
Evidence Score (E-score) 2 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [8]
Hydrolysis-driven transporters [+] 2 Hydrolysis-driven transporters +
Interacting Protein Name Protein sel-1 homolog 1 (SEL1L) Interacting Protein Interacting Protein Info
UniProt ID
SE1L1_HUMAN 
Synonyms PRO1063; SEL1.LIKE; SEL1L1
Evidence Score (E-score) 11 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [11]
3 Affinity Capture-Western [12]
4 Affinity Capture-Western [13]
5 Affinity Capture-Western [5]
6 Affinity Capture-Western [7]
7 Affinity Capture-Western [8]
8 Affinity Capture-Western [3]
9 Affinity Capture-Western [14]
10 Affinity Capture-Western [15]
11 Co-fractionation [5]
Interacting Protein Name Derlin-1 (DERL1) Interacting Protein Interacting Protein Info
UniProt ID
DERL1_HUMAN 
Synonyms DER.1; DER1
Evidence Score (E-score) 6 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [2]
3 Affinity Capture-Western [16]
4 Affinity Capture-Western [12]
5 Affinity Capture-Western [13]
6 Co-fractionation [5]
Pore-forming toxins [+] 1 Pore-forming toxins +
Interacting Target Name Cellular tumor antigen p53 (TP53) Clinical trial Target Interacting Protein Info
UniProt ID
P53_HUMAN 
Synonyms Tumor suppressor p53; Phosphoprotein p53; P53; Antigen NY-CO-13
Evidence Score (E-score) 5 Experimental Evidences +
1 Affinity Capture-Western [11]
2 Affinity Capture-Western [17]
3 Biochemical Activity [17]
4 Co-localization [17]
5 Reconstituted Complex [17]
Ubiquitin related proteins [+] 2 Ubiquitin related proteins +
Interacting Protein Name Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1) Interacting Protein Interacting Protein Info
UniProt ID
HERP1_HUMAN 
Synonyms HERP; Mif1; SUP
Evidence Score (E-score) 7 Experimental Evidences +
1 Affinity Capture-Western [1]
2 Affinity Capture-Western [12]
3 Affinity Capture-Western [8]
4 Affinity Capture-Western [18]
5 Affinity Capture-Western [3]
6 Co-fractionation [18]
7 Co-fractionation [5]
Interacting Protein Name Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) Interacting Protein Interacting Protein Info
UniProt ID
UB2J1_HUMAN 
Synonyms HSPC153; HSPC205; HSU93243; NCUBE.1; NCUBE1; UBC6; Ubc6p
Evidence Score (E-score) 3 Experimental Evidences +
1 Affinity Capture-MS [7]
2 Affinity Capture-Western [7]
3 Affinity Capture-Western [8]
References  Top
REF 1 The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway. J Mol Biol. 2005 Dec 16;354(5):1021-7.
REF 2 Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane. Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14132-8.
REF 3 gp78 functions downstream of Hrd1 to promote degradation of misfolded proteins of the endoplasmic reticulum. Mol Biol Cell. 2015 Dec 1;26(24):4438-50.
REF 4 Ataxin-3 binds VCP/p97 and regulates retrotranslocation of ERAD substrates. Hum Mol Genet. 2006 Aug 15;15(16):2409-20.
REF 5 Association of the SEL1L protein transmembrane domain with HRD1 ubiquitin ligase regulates ERAD-L. FEBS J. 2016 Jan;283(1):157-72.
REF 6 Structural and mechanistic insights into the arginine/lysine-rich peptide motifs that interact with P97/VCP. Biochim Biophys Acta. 2013 Dec;1834(12):2672-8.
REF 7 Defining human ERAD networks through an integrative mapping strategy. Nat Cell Biol. 2011 Nov 27;14(1):93-105.
REF 8 Conserved cytoplasmic domains promote Hrd1 ubiquitin ligase complex formation for ER-associated degradation (ERAD). J Cell Sci. 2017 Oct 1;130(19):3322-3335.
REF 9 A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin. J Neurochem. 2006 Dec;99(6):1456-69.
REF 10 [Protective effects of HRD1 and 4-phenylbutyric acid against neuronal cell death]. Nihon Yakurigaku Zasshi. 2004 Dec;124(6):391-8.
REF 11 Silencing of the SNARE protein NAPA sensitizes cancer cells to cisplatin by inducing ERK1/2 signaling, synoviolin ubiquitination and p53 accumulation. Biochem Pharmacol. 2011 Dec 1;82(11):1630-40.
REF 12 Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum. J Biol Chem. 2013 Aug 30;288(35):25330-9.
REF 13 A high-coverage shRNA screen identifies TMEM129 as an E3 ligase involved in ER-associated protein degradation. Nat Commun. 2014 May 8;5:3832.
REF 14 Human XTP3-B forms an endoplasmic reticulum quality control scaffold with the HRD1-SEL1L ubiquitin ligase complex and BiP. J Biol Chem. 2008 Jul 25;283(30):20914-24.
REF 15 Role of HERP and a HERP-related protein in HRD1-dependent protein degradation at the endoplasmic reticulum. J Biol Chem. 2014 Feb 14;289(7):4444-54.
REF 16 The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation. Mol Biol Cell. 2010 Jan 1;21(1):140-51.
REF 17 Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'. EMBO J. 2007 Jan 10;26(1):113-22.
REF 18 Herp regulates Hrd1-mediated ubiquitylation in a ubiquitin-like domain-dependent manner. J Biol Chem. 2011 Feb 18;286(7):5151-6.

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