Target Interacting Protein Information
Target General Information | Top | ||||
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Target ID | T00933 | Target Info | |||
Target Name | Histone lysine demethylase PHF8 (PHF8) | ||||
Synonyms | ZNF422; PHD finger protein 8; KIAA1111 | ||||
Target Type | Literature-reported Target | ||||
Gene Name | PHF8 | ||||
Biochemical Class | Paired donor oxygen oxidoreductase | ||||
UniProt ID |
Target Interacting Proteins | Top | ||||
---|---|---|---|---|---|
Histones | [+] 1 Histones | + | |||
Interacting Protein Name | Histone H3.1 (H31) | Interacting Protein | Interacting Protein Info | ||
UniProt ID | |||||
Synonyms | H3/A; H3FA | ||||
Evidence Score (E-score) | 10 Experimental Evidences | + | |||
1 | Affinity Capture-Western | [1] | |||
2 | Biochemical Activity | [2] | |||
3 | Biochemical Activity | [1] | |||
4 | Biochemical Activity | [3] | |||
5 | Biochemical Activity | [4] | |||
6 | Biochemical Activity | [5] | |||
7 | Biochemical Activity | [6] | |||
8 | Reconstituted Complex | [3] | |||
9 | Reconstituted Complex | [1] | |||
10 | Reconstituted Complex | [6] |
References | Top | ||||
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REF 1 | The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation. Cell Res. 2010 Aug;20(8):908-18. | ||||
REF 2 | PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. Nat Struct Mol Biol. 2010 Apr;17(4):445-50. | ||||
REF 3 | A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell. 2010 Apr 23;38(2):165-78. | ||||
REF 4 | Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature. 2010 Jul 22;466(7305):503-7. | ||||
REF 5 | PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis. Cell Res. 2010 Jul;20(7):794-801. | ||||
REF 6 | PHF8 targets histone methylation and RNA polymerase II to activate transcription. Mol Cell Biol. 2010 Jul;30(13):3286-98. |
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