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Target General Information |
Top |
Target ID |
T64022 |
Target Info
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Target Name |
Importin beta (KPNB1) |
Synonyms |
Pore targeting complex 97 kDa subunit; PTAC97; Nuclear factor p97; NTF97; Karyopherin subunit beta1; Karyopherin subunit beta-1; Importin90; Importin-90; Importin subunit beta1; Importin subunit beta-1 |
Target Type |
Literature-reported Target |
Gene Name |
KPNB1 |
Biochemical Class |
Eukaryotic nuclear pore complex |
UniProt ID |
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The microRNAs (miRNAs) Regulating This Target |
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miRNA Mature ID |
hsa-miR-30d-5p |
miRNA Info
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miRNA Mature AC |
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Sequence |
uguaaacauccccgacuggaag
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miRNA Species |
Homo sapiens |
Regulation Mechanism |
miR-30d mimic significantly reduced the activity of the wild-type KPNB1 3 UTR reporter while having little effect on mutant KPNB1 3'UTR reporter activity. |
[1] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay; Western Blot |
[1] |
Representative Target(s) Regulated by This miRNA |
Autophagy-related 2B (ATG2B)
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Target Info
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Beclin-1 (BECN1)
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Target Info
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References |
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REF 1 |
EZH2-miR-30d-KPNB1 pathway regulates malignant peripheral nerve sheath tumour cell survival and tumourigenesis. J Pathol. 2014 Feb;232(3):308-18.
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