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| Target General Information |
Top |
| Target ID |
T55781 |
Target Info
|
| Target Name |
Tyrosine-protein kinase Mer (MERTK) |
| Synonyms |
Receptor tyrosine kinase MerTK; Proto-oncogene c-Mer |
| Target Type |
Clinical trial Target |
| Gene Name |
MERTK |
| Biochemical Class |
Kinase |
| UniProt ID |
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| The microRNAs (miRNAs) Regulating This Target |
Top |
| miRNA Mature ID |
hsa-miR-126-3p |
miRNA Info
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| miRNA Mature AC |
|
| Sequence |
ucguaccgugaguaauaaugcg
|
| miRNA Species |
Homo sapiens |
| Regulation Mechanism |
miR-126 directly targets gene MERTK. |
[2] |
| Evidence Score (E-score) |
2 |
+ |
| 1 |
Dual Luciferase Reporter Assay |
[1] |
| 2 |
ELISA; Luciferase Reporter Assay; Western Blot |
[2] |
| Representative Target(s) Regulated by This miRNA |
Adrenomedullin (ADM)
|
Target Info
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|
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Angiopoietin 1 receptor (TEK)
|
Target Info
|
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| miRNA Mature ID |
hsa-miR-335-5p |
miRNA Info
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| miRNA Mature AC |
|
| Sequence |
ucaagagcaauaacgaaaaaugu
|
| miRNA Species |
Homo sapiens |
| Evidence Score (E-score) |
1 |
+ |
| 1 |
Luciferase Reporter Assay |
[3] |
| Representative Target(s) Regulated by This miRNA |
Apoptosis inhibitor survivin (BIRC5)
|
Target Info
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|
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Apoptosis regulator Bcl-W (BCL-W)
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Target Info
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| References |
Top |
| REF 1 |
MicroRNA-126 overexpression rescues diabetes-induced impairment in efferocytosis of apoptotic cardiomyocytes. Sci Rep. 2016 Nov 9;6:36207.
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| REF 2 |
A microRNA regulon that mediates endothelial recruitment and metastasis by cancer cells. Nature. 2011 Dec 14;481(7380):190-4.
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| REF 3 |
Endogenous human microRNAs that suppress breast cancer metastasis. Nature. 2008 Jan 10;451(7175):147-52.
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