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Target General Information |
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Target ID |
T23191 |
Target Info
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Target Name |
Orphan nuclear receptor DAX-1 (NR0B1) |
Synonyms |
Nuclear receptor subfamily 0 group B member 1; Nuclear receptor DAX-1; DSS-AHC critical region on the X chromosome protein 1; DAX1; AHC |
Target Type |
Literature-reported Target |
Gene Name |
NR0B1 |
Biochemical Class |
Nuclear hormone receptor |
UniProt ID |
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The microRNAs (miRNAs) Regulating This Target |
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miRNA Mature ID |
hsa-miR-561-3p |
miRNA Info
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miRNA Mature AC |
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Sequence |
caaaguuuaagauccuugaagu
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miRNA Species |
Homo sapiens |
Regulation Mechanism |
Overexpression of miR-561 decreased NR0B1-3'UTR reporter activity. |
[1] |
Evidence Score (E-score) |
1 |
+ |
1 |
Luciferase Reporter Assay |
[1] |
Representative Target(s) Regulated by This miRNA |
Orphan nuclear receptor DAX-1 (NR0B1)
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Target Info
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Proto-oncogene c-Myc (MYC)
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Target Info
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References |
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REF 1 |
MicroRNA-561 promotes acetaminophen-induced hepatotoxicity in HepG2 cells and primary human hepatocytes through downregulation of the nuclear receptor corepressor dosage-sensitive sex-reversal adrenal hypoplasia congenital critical region on the X chromosome, gene 1 (DAX-1). Drug Metab Dispos. 2014 Jan;42(1):44-61.
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