Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T99338 | Target Info | |||
| Target Name | Stimulator of interferon genes protein (TMEM173) | ||||
| Synonyms | Mediator of IRF3 activation; Endoplasmic reticulum interferon stimulator; ERIS | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | TMEM173 | ||||
| Biochemical Class | TMEM173 family | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-difluoro-34,39-disulfanyl-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34,39-diphosphaoctacyclo[28.6.4.1~3,36~.1~28,31~.0~4,8~.0~7,12~.0~19,24~.0~23,27~]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene 34,39-dioxide (non-preferred name) | Ligand Info | |||
| PubChem Substance ID | 440236186 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 6XF3 Crystal structure of STING in complex with E7766 | ||||||
| Method | X-ray diffraction | Resolution | 2.38 Å | Mutation | Yes | [1] |
| PDB Sequence |
SVAHGLAWSY
163 YIGYLRLILP173 ELQARIRTYN183 QHYNNLLRGA193 VSQRLYILLP203 LDCGVPDNLS 213 MADPNIRFLD223 KLPQQTGDRA233 GIKDRVYSNS243 IYELLENGQR253 AGTCVLEYAT 263 PLQTLFAMFS280 REDRLEQAKL290 FCRTLEDILA300 DAPESQNNCR310 LIAYQEPSFS 324 LSQEVLRHLR334 QEE
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| PDB ID: 6XF4 Crystal structure of STING REF variant in complex with E7766 | ||||||
| Method | X-ray diffraction | Resolution | 2.77 Å | Mutation | No | [1] |
| PDB Sequence |
SVAHGLAWSY
163 YIGYLRLILP173 ELQARIRTYN183 QHYNNLLRGA193 VSQRLYILLP203 LDCGVPDNLS 213 MADPNIRFLD223 KLPQQTGDHA233 GIKDRVYSNS243 IYELLENGQR253 AGTCVLEYAT 263 PLQTLFAMFS280 REDRLEQAKL290 FCRTLEDILA300 DAPESQNNCR310 LIAYQEPSFS 324 LSQEVLRHLR334 QEEK
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity. ChemMedChem. 2021 Jun 7;16(11):1740-1743. | ||||
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