Target Binding Site Detail

Content Navigation (  All   None )                                      
Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T97592 Target Info
Target Name Aurora kinase C (AURKC)
Synonyms Serine/threonine-protein kinase aurora-C; STK13; Aurora/Ipl1/Eg2 protein 2; Aurora/Ipl1-related kinase 3; Aurora-related kinase 3; Aurora-C; Aurora 3; ARK3; ARK-3; AIRK3; AIK3; AIE2
Target Type Clinical trial Target
Gene Name AURKC
Biochemical Class Kinase
UniProt ID
AURKC_HUMAN
Ligand General Information  Top
Ligand Name Phosphonothreonine Ligand Info
Canonical SMILES CC(C(C(=O)O)N)OP(=O)(O)O
InChI 1S/C4H10NO6P/c1-2(3(5)4(6)7)11-12(8,9)10/h2-3H,5H2,1H3,(H,6,7)(H2,8,9,10)/t2-,3+/m1/s1
InChIKey USRGIUJOYOXOQJ-GBXIJSLDSA-N
PubChem Compound ID 3246323
Drug Binding Sites of Target  Top
PDB ID: 6GR8      Human AURKC INCENP complex bound to BRD-7880
Method X-ray diffraction Resolution 1.75 Å Mutation No [1]
PDB Sequence
GANSRRLVDD
42
FEIGRPLGKG
52
KFGNVYLARL
62
KESHFIVALK
72
VLFKSQIEKE
82

GLEHQLRREI
92
EIQAHLQHPN
102
ILRLYNYFHD
112
ARRVYLILEY
122
APRGELYKEL
132

QKSDKLDEQR
142
TATIIEELAD
152
ALTYCHDKKV
162
IHRDIKPENL
172
LLGFRGEVKI
182

ADFGWSVHTP
192
SLRRKMCGTL
203
DYLPPEMIEG
213
RTYDEKVDLW
223
CIGVLCYELL
233

VGYPPFESAS
243
HSETYRRILK
253
VDVRFPLSMP
263
LGARDLISRL
273
LRYQPLERLP
283

LAQILKHPWV
293
QAHSRRVLPP
303
Residue
Distance (Å)
ARG37
3.476
LEU38
1.342
VAL40
1.341
ASP41
3.063
ASP42
2.821
PHE43
3.428
ARG90
2.793
PHE110
3.602
ARG165
2.762
Residue
Distance (Å)
TRP187
4.761
VAL189
4.480
ARG196
2.873
LYS197
1.342
MET199
1.342
CYS200
3.391
MET210
4.113
TYR216
2.625
PDB ID: 6GR9      Human AURKC INCENP complex bound to VX-680
Method X-ray diffraction Resolution 2.25 Å Mutation No [2]
PDB Sequence
RLVDDFEIGR
47
PLGKGKFGNV
57
YLARLKESHF
67
IVALKVLFKS
77
QIEKEGLEHQ
87

LRREIEIQAH
97
LQHPNILRLY
107
NYFHDARRVY
117
LILEYAPRGE
127
LYKELQKSDK
137

LDEQRTATII
147
EELADALTYC
157
HDKKVIHRDI
167
KPENLLLGFR
177
GEVKIADFGW
187

SVHTPSLRRK
197
MCGTLDYLPP
208
EMIEGRTYDE
218
KVDLWCIGVL
228
CYELLVGYPP
238

FESASHSETY
248
RRILKVDVRF
258
PLSMPLGARD
268
LISRLLRYQP
278
LERLPLAQIL
288

KHPWVQAHSR
298
RVLPPCA
Residue
Distance (Å)
ARG37
3.419
LEU38
1.345
VAL40
1.338
ASP41
2.887
ASP42
2.837
PHE43
3.475
PHE110
3.633
ARG165
2.756
Residue
Distance (Å)
TRP187
4.670
ARG196
3.206
LYS197
1.340
MET199
1.333
CYS200
3.295
MET210
4.179
TYR216
2.597
References  Top
REF 1 AURKC INCENP complex bound to BRD-7880
REF 2 AURKC INCENP complex bound to BRD-7880

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.