Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95682 | Target Info | |||
| Target Name | Bromodomain adjacent to zinc finger 2A (BAZ2A) | ||||
| Synonyms | hWALp3; Transcription termination factor I-interacting protein 5; Tip5; TTF-I-interacting protein 5; KIAA0314; Bromodomain adjacent to zinc finger domain protein 2A | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | BAZ2A | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | 5-ethyl-2-(3-methyl-1,2,3-triazol-4-yl)-1~{H}-benzimidazole | Ligand Info | |||
| Canonical SMILES | CCC1=CC2=C(C=C1)N=C(N2)C3=CN=NN3C | ||||
| InChI | 1S/C12H13N5/c1-3-8-4-5-9-10(6-8)15-12(14-9)11-7-13-16-17(11)2/h4-7H,3H2,1-2H3,(H,14,15) | ||||
| InChIKey | ODOFHRIEFOAOCH-UHFFFAOYSA-N | ||||
| PubChem Compound ID | 136518179 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7B7B BAZ2A bromodomain in complex with triazole compound MS04 | ||||||
| Method | X-ray diffraction | Resolution | 1.40 Å | Mutation | Yes | [1] |
| PDB Sequence |
SMHSDLTFCE
1803 IILMEMESHD1813 AAWPFLEPVN1823 PRLVSGYRRI1833 IKNPMDFSTM1843 RHRLSRGGYT 1853 SSEEFAADAL1863 LVFDNCQTFN1873 EDDSEVGKAG1883 HIMRRFFESR1893 WEEFY |
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| PDB ID: 7B7G BAZ2A bromodomain in complex with compounds MS04 and B11 | ||||||
| Method | X-ray diffraction | Resolution | 1.43 Å | Mutation | Yes | [1] |
| PDB Sequence |
SMHSDLTFCE
1803 IILMEMESHD1813 AAWPFLEPVN1823 PRLVSGYRRI1833 IKNPMDFSTM1843 RHRLSRGGYT 1853 SSEEFAADAL1863 LVFDNCQTFN1873 EDDSEVGKAG1883 HIMRRFFESR1893 WEEFY |
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of a BAZ2A-Bromodomain Hit Compound by Fragment Growing. ACS Med Chem Lett. 2022 Aug 3;13(9):1434-1443. | ||||
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