Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95438 | Target Info | |||
| Target Name | Excitatory amino acid transporter 2 (SLC1A2) | ||||
| Synonyms | Solute carrier family 1 member 2; Sodium-dependent glutamate/aspartate transporter 2; Glutamate/aspartatetransporter II; Glutamate/aspartate transporter II; GLT1; EAAT2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SLC1A2 | ||||
| Biochemical Class | Dicarboxylate/amino acid:cation symporter | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | Cholesterol hemisuccinate | Ligand Info | |||
| Canonical SMILES | CC(C)CCCC(C)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)CCC(=O)O)C)C | ||||
| InChI | 1S/C31H50O4/c1-20(2)7-6-8-21(3)25-11-12-26-24-10-9-22-19-23(35-29(34)14-13-28(32)33)15-17-30(22,4)27(24)16-18-31(25,26)5/h9,20-21,23-27H,6-8,10-19H2,1-5H3,(H,32,33)/t21-,23+,24+,25-,26+,27+,30+,31-/m1/s1 | ||||
| InChIKey | WLNARFZDISHUGS-MIXBDBMTSA-N | ||||
| PubChem Compound ID | 65082 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7XR4 Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with glutamate | ||||||
| Method | Electron microscopy | Resolution | 3.40 Å | Mutation | No | [1] |
| PDB Sequence |
LCDKLGKNLL
46 LTLTVFGVIL56 GAVCGGLLRL66 ASPIHPDVVM76 LIAFPGDILM86 RMLKMLILPL 96 IISSLITGLS106 GLDAKASGRL116 GTRAMVYYMS126 TTIIAAVLGV136 ILVLAIHPGN 146 PKVSSLDAFL169 DLIRNLFPEN179 LVQACFQQIQ189 TVTKKVVIKK232 GLEFKDGMNV 242 LGLIGFFIAF252 GIAMGKMGDQ262 AKLMVDFFNI272 LNEIVMKLVI282 MIMWYSPLGI 292 ACLICGKIIA302 IKDLEVVARQ312 LGMYMVTVII322 GLIIHGGIFL332 PLIYFVVTRK 342 NPFSFFAGIF352 QAWITALGTA362 SSAGTLPVTF372 RCLEENLGID382 KRVTRFVLPV 392 GATINMDGTA402 LYEAVAAIFI412 AQMNGVVLDG422 GQIVTVSLTA432 TLASVGAASI 442 PSAGLVTMLL452 ILTAVGLPTE462 DISLLVAVDW472 LLDRMRTSVN482 VVGDSFGAGI 492 VYHLSKSELD502 TIDSQ
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| PDB ID: 7XR6 Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with WAY-213613 | ||||||
| Method | Electron microscopy | Resolution | 3.40 Å | Mutation | No | [1] |
| PDB Sequence |
RLCDKLGKNL
45 LLTLTVFGVI55 LGAVCGGLLR65 LASPIHPDVV75 MLIAFPGDIL85 MRMLKMLILP 95 LIISSLITGL105 SGLDAKASGR115 LGTRAMVYYM125 STTIIAAVLG135 VILVLAIHPG 145 NPKVSSLDAF168 LDLIRNLFPE178 NLVQACFQQI188 QTVTKVIKKG233 LEFKDGMNVL 243 GLIGFFIAFG253 IAMGKMGDQA263 KLMVDFFNIL273 NEIVMKLVIM283 IMWYSPLGIA 293 CLICGKIIAI303 KDLEVVARQL313 GMYMVTVIIG323 LIIHGGIFLP333 LIYFVVTRKN 343 PFSFFAGIFQ353 AWITALGTAS363 SAGTLPVTFR373 CLEENLGIDK383 RVTRFVLPVG 393 ATINMDGTAL403 YEAVAAIFIA413 QMNGVVLDGG423 QIVTVSLTAT433 LASVGAASIP 443 SAGLVTMLLI453 LTAVGLPTED463 ISLLVAVDWL473 LDRMRTSVNV483 VGDSFGAGIV 493 YHLSKSELDT503 IDSQ
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural basis of ligand binding modes of human EAAT2. Nat Commun. 2022 Jun 9;13(1):3329. | ||||
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