Target Binding Site Detail
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95438 | Target Info | |||
| Target Name | Excitatory amino acid transporter 2 (SLC1A2) | ||||
| Synonyms | Solute carrier family 1 member 2; Sodium-dependent glutamate/aspartate transporter 2; Glutamate/aspartatetransporter II; Glutamate/aspartate transporter II; GLT1; EAAT2 | ||||
| Target Type | Literature-reported Target | ||||
| Gene Name | SLC1A2 | ||||
| Biochemical Class | Dicarboxylate/amino acid:cation symporter | ||||
| UniProt ID | |||||
| Ligand General Information | Top | ||||
|---|---|---|---|---|---|
| Ligand Name | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en | Ligand Info | |||
| Canonical SMILES | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)OCCC(COC)COC)C)C)C)OC1 | ||||
| InChI | 1S/C34H56O5/c1-22-9-15-34(38-19-22)23(2)31-30(39-34)18-29-27-8-7-25-17-26(37-16-12-24(20-35-5)21-36-6)10-13-32(25,3)28(27)11-14-33(29,31)4/h7,22-24,26-31H,8-21H2,1-6H3/t22-,23+,26+,27-,28+,29+,30+,31+,32+,33+,34-/m1/s1 | ||||
| InChIKey | CEEBZAXXSRFQIC-GZSGZGDASA-N | ||||
| PubChem Compound ID | 134817783 | ||||
| Drug Binding Sites of Target | Top | |||||
|---|---|---|---|---|---|---|
| PDB ID: 7VR7 Inward-facing structure of human EAAT2 in the WAY213613-bound state | ||||||
| Method | Electron microscopy | Resolution | 3.49 Å | Mutation | No | [1] |
| PDB Sequence |
NLLLTLTVFG
53 VILGAVCGGL63 LRLASPIHPD73 VVMLIAFPGD83 ILMRMLKMLI93 LPLIISSLIT 103 GLSGLDGRLG117 TRAMVYYMST127 TIIAAVLGVI137 LVLAIHPGNP147 SSLDAFLDLI 172 RNLFPENLVQ182 ACFQQIQTVT192 KIKKGLEFKD238 GMNVLGLIGF248 FIAFGIAMGK 258 MGDQAKLMVD268 FFNILNEIVM278 KLVIMIMWYS288 PLGIACLICG298 KIIAIKDLEV 308 VARQLGMYMV318 TVIIGLIIHG328 GIFLPLIYFV338 VTRKNPFSFF348 AGIFQAWITA 358 LGTASSAGTL368 PVTFRCLEEN378 LGIDKRVTRF388 VLPVGATINM398 DGTALYEAVA 408 AIFIAQMNGV418 VLDGGQIVTV428 SLTATLASVG438 AASIPSAGLV448 TMLLILTAVG 458 LPTEDISLLV468 AVDWLLDRMR478 TSVNVVGDSF488 GAGIVYHLSK498 SE |
|||||
|
|
ILE93
4.929
LEU96
3.730
ILE97
3.898
SER100
3.526
LEU101
3.485
GLY104
3.815
LEU105
4.066
LEU108
3.187
ASP109
3.623
MET121
3.868
ILE246
4.252
PHE388
4.164
|
|||||
| PDB ID: 7VR8 Inward-facing structure of human EAAT2 in the substrate-free state | ||||||
| Method | Electron microscopy | Resolution | 3.58 Å | Mutation | No | [1] |
| PDB Sequence |
NLLLTLTVFG
53 VILGAVCGGL63 LRLASPIHPD73 VVMLIAFPGD83 ILMRMLKMLI93 LPLIISSLIT 103 GLSGLDGRLG117 TRAMVYYMST127 TIIAAVLGVI137 LVLAIHPGNP147 SSLDAFLDLI 172 RNLFPENLVQ182 ACFQQIQTVT192 KIKKGLEFKD238 GMNVLGLIGF248 FIAFGIAMGK 258 MGDQAKLMVD268 FFNILNEIVM278 KLVIMIMWYS288 PLGIACLICG298 KIIAIKDLEV 308 VARQLGMYMV318 TVIIGLIIHG328 GIFLPLIYFV338 VTRKNPFSFF348 AGIFQAWITA 358 LGTASSAGTL368 PVTFRCLEEN378 LGIDKRVTRF388 VLPVGATINM398 DGTALYEAVA 408 AIFIAQMNGV418 VLDGGQIVTV428 SLTATLASVG438 AASIPSAGLV448 TMLLILTAVG 458 LPTEDISLLV468 AVDWLLDRMR478 TSVNVVGDSF488 GAGIVYHLSK498 SE |
|||||
|
|
ILE93
4.982
LEU96
3.792
ILE97
3.836
SER100
3.426
LEU101
3.346
GLY104
3.531
LEU105
3.471
LEU108
3.152
ASP109
3.451
MET121
4.752
ILE246
3.858
PHE388
3.609
|
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| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2. Nat Commun. 2022 Aug 11;13(1):4714. | ||||
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