Target Binding Site Detail

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Target General Information
Ligand General Information
Drug Binding Sites of Target
References
Target General Information  Top
Target ID T92639 Target Info
Target Name Alpha-tubulin N-acetyltransferase 1 (ATAT1)
Synonyms MEC17; C6orf134; Alpha-TAT; Acetyltransferase mec-17 homolog
Target Type Literature-reported Target
Gene Name ATAT1
Biochemical Class Acetyltransferase ATAT1 family
UniProt ID
ATAT_HUMAN
Ligand General Information  Top
Ligand Name Selenomethionine Ligand Info
Canonical SMILES C[Se]CCC(C(=O)O)N
InChI 1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)
InChIKey RJFAYQIBOAGBLC-UHFFFAOYSA-N
PubChem Compound ID 15103
Drug Binding Sites of Target  Top
PDB ID: 4GS4      Structure of the alpha-tubulin acetyltransferase, alpha-TAT1
Method X-ray diffraction Resolution 2.11 Å Mutation No [1]
PDB Sequence
FPFDVDALFP
12
ERITVLDQHL
22
RPPVDLQQQI
43
TIIDELGKAS
54
AKAQNLSAPI
64

TSASRQSNRH
75
VVYILKDSAI
93
IGFIKVGYKK
103
LFVLDDREAH
113
NEVEPLCILD
123

FYIHESVQRH
133
GHGRELFQYL
144
QKERVEPHQL
154
AIDRPSQKLL
164
KFLNKHYNLE
174

TTVPQVNNFV
184
IFEGFFAHQH
194
R
Residue
Distance (Å)
LEU18
4.018
ASP19
3.521
GLN20
3.192
LEU22
4.530
GLN40
3.097
GLN41
3.315
GLN42
3.239
ILE43
1.333
THR45
1.332
ILE46
3.066
ILE47
3.015
ASP48
2.750
GLU49
4.801
THR65
4.723
SER66
3.031
ALA67
3.266
SER68
3.583
ARG69
1.331
GLN71
1.330
SER72
3.258
ASN73
3.479
Residue
Distance (Å)
HIS75
3.253
VAL76
4.363
VAL77
3.642
TYR78
3.743
ILE97
4.216
LYS98
3.904
VAL99
3.413
LEU119
3.709
ILE121
3.724
LEU139
3.225
PHE140
3.326
GLN141
3.284
TYR142
1.329
LEU144
1.333
GLN145
3.163
LYS146
3.289
GLU147
2.874
ARG148
4.532
VAL149
3.854
LEU154
4.387
PDB ID: 4IF5      Structure of human Mec17
Method X-ray diffraction Resolution 1.70 Å Mutation No [2]
PDB Sequence
HEFPFDVDAL
10
FPERITVLDQ
20
HLRPPARRPG
30
TTTPARVDLQ
40
QQITIIDELG
51

KASAKAQNLS
61
APITSASRQS
72
NRHVVYILKD
82
SSARPAGKGA
92
IIGFIKVGYK
102

KLFVLDDREA
112
HNEVEPLCIL
122
DFYIHESVQR
132
HGHGRELFQY
142
LQKERVEPHQ
153

LAIDRPSQKL
163
LKFLNKHYNL
173
ETTVPQVNNF
183
VIFEGFFA
Residue
Distance (Å)
HIS-1
1.331
GLU2
1.330
PHE3
3.718
LEU18
3.630
ASP19
3.669
GLN20
3.435
LEU22
3.676
GLN40
2.865
GLN41
3.244
GLN42
3.299
ILE43
1.326
THR45
1.325
ILE46
3.338
ILE47
3.471
ASP48
2.900
GLU49
4.989
LEU50
3.619
ALA53
4.396
SER66
2.870
ALA67
3.237
SER68
3.279
ARG69
1.327
GLN71
1.325
SER72
3.293
ASN73
3.077
ARG74
4.988
HIS75
3.669
Residue
Distance (Å)
VAL76
4.540
VAL77
3.775
TYR78
3.675
GLY91
4.392
ALA92
3.743
ILE93
3.267
ILE94
3.687
GLY95
4.305
ILE97
4.126
LYS98
4.224
VAL99
3.878
LEU119
4.224
ILE121
3.627
TYR125
3.889
HIS127
3.964
LEU139
3.036
PHE140
3.217
GLN141
3.306
TYR142
1.329
LEU144
1.332
GLN145
3.149
LYS146
3.248
GLU147
2.858
ARG148
4.526
VAL149
4.602
LEU154
4.640
References  Top
REF 1 Structure of the Alpha-tubulin acetyltransferase, AlphaTAT1, and implications for tubulin-specific acetylation. Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19655-60.
REF 2 Structural and functional characterization of the Alpha-tubulin acetyltransferase MEC-17. J Mol Biol. 2014 Jul 15;426(14):2605-16.

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